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Emotional Stop Cues Facilitate Inhibitory Control in Schizophrenia

Published online by Cambridge University Press:  07 November 2019

Qi Zheng ,
Tian-Xiao Yang Open the ORCID record for Tian-Xiao Yang [Opens in a new window]  and
Zheng Ye
Qi Zheng
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Tian-Xiao Yang*
Affiliation:
CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, China Department of Psychology, University of Chinese Academy of Sciences, Beijing, China
Zheng Ye*
Affiliation:
Institute of Neuroscience, Key Laboratory of Primate Neurobiology, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China
*
*Correspondence and reprint requests to: Tian-xiao Yang, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China. E-mail: yangtx@psych.ac.cn; Zheng Ye, Institute of Neuroscience, Chinese Academy of Sciences, Yueyang Road 320, Shanghai 200031, China, E-mail: yez@ion.ac.cn
*Correspondence and reprint requests to: Tian-xiao Yang, Institute of Psychology, Chinese Academy of Sciences, 16 Lincui Road, Beijing 100101, China. E-mail: yangtx@psych.ac.cn; Zheng Ye, Institute of Neuroscience, Chinese Academy of Sciences, Yueyang Road 320, Shanghai 200031, China, E-mail: yez@ion.ac.cn
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Abstract

Objective:

Inhibitory control is a key deficit in patients with schizophrenia. This study aims to test whether emotions can facilitate inhibition in patients with schizophrenia when they increase attention to inhibitory process.

Method:

A total of 36 patients with schizophrenia and 36 healthy controls completed an emotional stop-signal task. The task involved selective responses to “Go” stimuli and stopped response when emotional or neutral stop cues occurred.

Results:

In all conditions, patients with schizophrenia took longer time to inhibit response compared with healthy controls, indicating an overall impairment in response inhibition. Importantly, patients with schizophrenia and controls acquired similar size of benefit from the negative stop cues, showing as reduced reaction time to negative than neutral stop cues. However, the negative stop cues impaired subsequent Go performance only in patients with schizophrenia, indicating additional cost of the negative stop cues for patients with schizophrenia. In both groups, the positive stop cues did not have any significant influence on response inhibition.

Conclusions:

These findings provide novel evidence for the benefit of emotional stop cues on inhibitory control in patients with schizophrenia and reveal different after-effects of emotional enhancement effect in patients and healthy populations. The findings may help develop effective interventions for improving inhibitory control in patients with schizophrenia and other clinical populations.

Keywords

SchizophreniaResponse inhibitionEmotionStop-signal taskCognitive enhancementExecutive function
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 26 , Issue 3 , March 2020 , pp. 286 - 293
Copyright
Copyright © INS. Published by Cambridge University Press, 2019

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