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Event-Based Prospective Memory in Newly Diagnosed, Drug-Naive Parkinson's Disease Patients

Published online by Cambridge University Press:  12 October 2011

Cristina Pagni ,
Daniela Frosini ,
Roberto Ceravolo ,
Giulia Giunti ,
Elisa Unti ,
Michele Poletti ,
Shawn M. McClintock ,
Luigi Murri ,
Ubaldo Bonuccelli  and
Gloria Tognoni
Cristina Pagni
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Daniela Frosini
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Roberto Ceravolo
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Giulia Giunti
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Elisa Unti
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Michele Poletti
Affiliation:
Neurology Unit, USL of Viareggio, Italy
Shawn M. McClintock
Affiliation:
Department of Psychiatry, Division of Psychology, UT Southwestern Medical Center, Dallas, Texas
Luigi Murri
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
Ubaldo Bonuccelli
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy Neurology Unit, USL of Viareggio, Italy
Gloria Tognoni*
Affiliation:
Neuroscience Department, University of Pisa, Pisa, Italy
*
Correspondence and reprint requests to: Gloria Tognoni, Dipartimento di Neuroscienze, via Roma 67, 56126, Pisa. E-mail: g.tognoni@neuro.med.unipi.it
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Abstract

The present study investigated memory for intention in individuals with Parkinson's disease (PD) who were newly diagnosed and not yet treated to avoid the effect of therapy as a potential confounding variable. A comprehensive neuropsychological battery and an event-based prospective memory task were administered to 41 subjects with de novo PD and 40 control subjects. Separate scores were computed for correct execution of intended action (prospective component) and recall of intention (retrospective component). PD patients performed marginally worse (p = .053) than controls on the prospective component of the task. On the other hand, the performance of the two groups was comparable for the retrospective component. Neuropsychological findings revealed lower performance of the PD group in episodic memory and in some measures of executive functions. These results suggested a subtle prospective memory dysfunction present at the initial stage of PD, which may be related to disruption of fronto-striatal circuitry. (JINS, 2011, 17, 1158–1162)

Keywords

IntentionParkinsonian disordersEpisodic memoryExecutive functionWorking memoryNeuropsychological test
Type
Brief Communications
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 6 , November 2011 , pp. 1158 - 1162
Copyright
Copyright © The International Neuropsychological Society 2011

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