Hostname: page-component-cd9895bd7-mkpzs Total loading time: 0 Render date: 2024-12-28T16:45:02.141Z Has data issue: false hasContentIssue false
  • English
  • Français

Frontal Defects Contribute to the Genesis of Closing-in in Alzheimer's Disease Patients

Published online by Cambridge University Press:  24 May 2013

Natascia De Lucia ,
Dario Grossi ,
Angiola Maria Fasanaro ,
Sabrina Carpi  and
Luigi Trojano
Natascia De Lucia
Affiliation:
Neuropsychology Lab, Department of Psychology, Second University of Naples, Italy
Dario Grossi
Affiliation:
Neuropsychology Lab, Department of Psychology, Second University of Naples, Italy
Angiola Maria Fasanaro
Affiliation:
Alzheimer's disease Unit, AORN ‘A. Cardarelli’, Naples, Italy
Sabrina Carpi
Affiliation:
Alzheimer's disease Unit, AORN ‘A. Cardarelli’, Naples, Italy
Luigi Trojano*
Affiliation:
Neuropsychology Lab, Department of Psychology, Second University of Naples, Italy
*
Correspondence and reprint requests to: Luigi Trojano, Neuropsychology Lab, Department of Psychology, Second University of Naples, Viale Ellittico 31, 81100 Caserta, Italy. E-mail: luigi.trojano@unina2.it
Get access Rights & Permissions [Opens in a new window]

Abstract

Closing-in (CI) refers to copying drawings near to or superimposed on the original model, and is often observed in Alzheimer's disease (AD) patients. Contrasting hypotheses have been suggested to explain CI, but no prospective study has directly verified these interpretations. We evaluated the role of frontal/executive versus visuo-spatial impairments in a prospective sample of AD patients, and also explored whether different types of CI are related to specific neuropsychological tasks. We enrolled 64 AD patients who underwent copying tasks and an extensive neuropsychological assessment of visuo-spatial and visuo-constructional skills, frontal/executive abilities and anterograde memory. AD patients with CI showed more severe impairment on frontal/executive functions than AD patients without CI. Moreover, the tendency to produce copies superimposed on the model was selectively associated with poor inhibitory control for irrelevant responses. On this basis, we suggest that different CI phenomena could be ascribed to distinctive frontal/executive defects. (JINS, 2013, 19, 1–7)

Keywords

DrawingInhibitory controlCognitive flexibilityVisuo-spatial skillsDementia
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 19 , Issue 7 , August 2013 , pp. 802 - 808
Copyright
Copyright © The International Neuropsychological Society 2013 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Ambron, E., Della Sala, S., McIntosh, R.D. (2012). Closing-in behaviour and motor distractibility. Neuropsychologia, 50, 419–425. doi:10.1016/j.neuropsychologia.2011.12.019CrossRefGoogle ScholarPubMed
Ambron, E., McIntosh, R.D., Allaria, F., Della Sala, S. (2009). A large-scale retrospective study of closing-in behavior in Alzheimer's disease. Journal of the International Neuropsychological Society, 15, 787–792. doi:10.1017/S1355617709990245CrossRefGoogle ScholarPubMed
Ambron, E., McIntosh, R.D., Della Sala, S. (2010). Closing-in behaviour in preschool children. Cognitive Processing, 15, 207–211. doi:10.1007/s10339-009-0264-0CrossRefGoogle Scholar
Ambron, E., McIntosh, R.D., Finotto, S., Clerici, F., Mariani, C., Della Sala, S. (2012). Closing-in behavior in mild cognitive impairment: An executive deficit. Journal of the International Neuropsychological Society, 18, 269–276. doi:10.1017/S1355617711001676CrossRefGoogle ScholarPubMed
Appollonio, I., Leone, M., Isella, V., Piamarta, F., Consoli, T., Villa, M.L., Nichelli, P. (2005). The Frontal Assessment Battery (FAB): Normative values in an Italian population sample. Neurological Sciences, 26, 108–116. doi:10.1007/s10072-005-0443-4CrossRefGoogle Scholar
Benjamini, Y., Hochberg, Y. (1995). Controlling the false discovery rate – a practical and powerful approach to multiple testing. Journal of the Royal Statistic Society: Series B (Methodological), 57, 289–300Google Scholar
Caltagirone, C., Gainotti, G., Carlesimo, G.A., Parnetti, L. (1995). Batteria per la valutazione del deterioramento mentale (parte I): Descrizione di uno strumento per la diagnosi neuropsicologica. Archivio di Psicologia, Neurologia e Psichiatria, 55, 461–470.Google Scholar
Caffarra, P., Vezzadini, G., Dieci, F., Zonato, F., Venneri, A. (2002a). Rey–Osterrieth complex figure: Normative values in an Italian population sample. Neurological Sciences, 22, 443–447.CrossRefGoogle Scholar
Caffarra, P., Vezzadini, G., Dieci, F., Zonato, F., Venneri, A. (2002b). Una versione abbreviata del test di Stroop. Dati normativi nella popolazione italiana. Nuova Rivista di Neurologia, 12, 111–115.Google Scholar
Carlesimo, G.A., Caltagirone, C., Gainotti, G., the group of the Standardization of the Mental Deterioration Battery. (1996). The mental deterioration battery: Normative data, diagnostic reliability and qualitative analyses of cognitive impairment. European Neurology, 36, 378–384.CrossRefGoogle ScholarPubMed
Conson, M., Salzano, S., Manzo, V., Grossi, D., Trojano, L. (2009). Closing-in without severe drawing disorders: The “fatal” consequences of pathological attraction. Cortex, 45, 285–292. doi:10.1016/j.cortex.2007.11.013CrossRefGoogle ScholarPubMed
Cosentino, S., Jefferson, A., Chute, D.L., Kaplan, E., Libon, D.J. (2004). Clock drawing errors in dementia: Neuropsychological and neuroanatomical considerations. Cognitive and Behavioural Neurology, 17, 74–84.CrossRefGoogle ScholarPubMed
Critchley, M. (1953). Constructional apraxia. In E. Arnold (Eds.), The parietal lobes (pp. 172–202). London, UK: Edward Arnold.Google Scholar
De Ajuriaguerra, J., Muller, M., Tissot, R. (1960). A propos de quelque problèmes posés par l'apraxie dans les démences. Encephale, 49, 375–401.Google Scholar
De Ajuriaguerra, J., Zazzo, R., Granjon, N. (1949). Le phenomene d'accolement au model (closing-in) dans une syndrome d'apraxie oxycarbonnée [The phenomenon of attraction to the model (closing-in) in a case of apraxia following carbon monooxide poisoning]. Encephale, 38, 1–20.Google Scholar
DeMaris, A. (2002). Explained variance in logistic regression: A Monte Carlo study of proposed measures. Sociological Methods & Research, 31, 27–74.CrossRefGoogle Scholar
Efron, B., Tibshirani, R.J. (1993). An Introduction to the Bootstrap. New York, NY: Chapman & Hall.CrossRefGoogle Scholar
Gainotti, G. (1972). A qualitative study of the closing-in symptom in normal children and in brain-damaged patients. Neuropsychologia, 10, 429–436.CrossRefGoogle Scholar
Gainotti, G., Marra, C., Villa, G., Parlato, V., Chiaretti, F. (1998). Sensitivity and specificity of some neuropsychological markers of Alzheimer dementia. Alzheimer Disease and Associated Disorders, 12, 152–162.CrossRefGoogle ScholarPubMed
Gainotti, G., Parlato, V., Monteleone, D., Carlomagno, S. (1992). Neuropsychological markers of dementia on visual-spatial tasks: A comparison between Alzheimer's type and vascular forms of dementia. Journal of Clinical and Experimental Neuropsychology, 14, 239–252.CrossRefGoogle ScholarPubMed
Gasparini, M., Masciarelli, G., Vanacore, N., Ottaviani, D., Salati, E., Talarico, G., Bruno, G. (2008). A descriptive study on constructional impairment in frontotemporal dementia and Alzheimer's disease. European Journal of Neurology, 15, 589–597. doi:10.1111/j.1468-1331.2008.02128.xCrossRefGoogle Scholar
Grossi, D., Fragassi, N.A., Chiacchio, L., Valoroso, L., Tuccillo, R., Perrotta, C., Trojano, L. (2002). Do visuospatial and constructional disturbances differentiate frontal variant of frontotemporal dementia and Alzheimer's disease? an experimental study of a clinical belief. International Journal of Geriatric Psychiatry, 17, 641–648.CrossRefGoogle ScholarPubMed
Hughes, C.P., Berg, L., Danziger, W.L., Coben, L.A., Martin, R.L. (1982). A new clinical scale for the staging of dementia. The British Journal of Psychiatry, 140, 566–572. doi:10.1192/bjp.140.6.566CrossRefGoogle ScholarPubMed
Kwak, Y.T. (2004). Closing-in phenomenon in Alzheimer's disease and subcortical vascular dementia. BMC Neurology, 4, 1–7.CrossRefGoogle ScholarPubMed
Kwon, J.C., Kang, S.J., Lee, B.H., Chin, J., Heilman, K.M., Na, D.L. (2002). Manual approach during hand gesture imitation. Archives of Neurology, 59, 1468–1475.CrossRefGoogle ScholarPubMed
Lee, B.H., Chin, J., Kang, S.J., Kim, E.J., Park, K.C., Na, D.L. (2004). Mechanism of the closing-in phenomenon in a figure coping task in Alzheimer's disease patients. Neurocase, 10, 393–397. doi:10.1080/13554790490892194CrossRefGoogle Scholar
Mayer Gross, W. (1935). Some observations on apraxia. Proceedings of the Royal Society of Medicine, 28, 63–72.Google ScholarPubMed
McIntosh, R.D., Ambron, E., Della Sala, S. (2008). Evidence for an attraction account of closing-in behaviour. Cognitive Neuropsychology, 25, 376–394. doi:10.1080/02643290802028981CrossRefGoogle ScholarPubMed
McKhann, G., Drachman, D., Folstein, M., Katzman, R., Price, D., Stadlan, E.M. (1984). Clinical diagnosis of Alzheimer's disease: Report of the NINCDS-ADRDA work group under the auspices of Department of Health and Human Services Task Force on Alzheimer's disease. Neurology, 34, 939–944. doi:10.1212/WNL.34.7.939CrossRefGoogle ScholarPubMed
Measso, G., Cavarzeran, F., Zappala, G., Lebowitz, B.D., Crook, T.H., Pirozzolo, F.J., Grigoletto, F. (1993). The Mini-Mental State Examination: Normative study of an Italian random sample. Developmental Neuropsychology, 9, 77–85. doi:10.1080/87565649109540545CrossRefGoogle Scholar
Mondini, S., Mapelli, D., Vestri, A., Bisiacchi, P.S. (2003). Esame Neuropsicologico Breve. Milan, MI: Cortina Editor.Google Scholar
Ober, B.A., Jagust, W.J., Koss, E., Delis, D.C., Friedland, R.P. (1991). Visuoconstructive performance and regional cerebral glucose metabolism in Alzheimer's disease. Journal of Clinical and Experimental Neuropsychology, 13, 752–772.CrossRefGoogle ScholarPubMed
Rouleau, I., Salmon, D.P., Butters, N. (1996). Longitudinal analysis of clock drawing in Alzheimer's disease patients. Brain and Cognition, 31, 17–34.CrossRefGoogle ScholarPubMed
Serra, L., Fadda, L., Perri, R., Caltagirone, C., Carlesimo, G.A. (2009). The closing-in phenomenon in the drawing performance of Alzheimer's disease patients: A compensation account. Cortex, 46, 1031–1036. doi:10.1016/j.cortex.2009.08.010CrossRefGoogle ScholarPubMed
Solms, M., Turnbull, O.H., Kaplan-Solms, K., Miller, P. (1998). Rotated drawing: The range of performance and anatomical correlates in a series of 16 patients. Brain and Cognition, 38, 358–368.CrossRefGoogle Scholar
Spinnler, H., Tognoni, G. (1987). Standardizzazione e taratura italiana di tests neuropsicologici. Italian Journal of Neurological Sciences, 6, 8–96.Google Scholar
Trojano, L., Conson, M. (2008). Visuospatial and visuoconstructive deficits. Handbook of Clinical Neurology, 88, 373–391. doi:10.1016/S0072-9752(07)88019-5CrossRefGoogle ScholarPubMed
Trojano, L., Grossi, D., Flash, T. (2009). Cognitive neuroscience of drawing: Contributions of neuropsychological, experimental and neurofunctional studies. Cortex, 45, 269–277. doi:10.1016/j.cortex.2008.11.015CrossRefGoogle ScholarPubMed