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Functional Correlates of Midline Brain Volume Loss in Chronic Traumatic Brain Injury

Published online by Cambridge University Press:  07 August 2015

Emma B. Guild  and
Brian Levine
Emma B. Guild
Affiliation:
Rotman Research Institute, Baycrest, Toronto, Canada Department of Psychology, University of Toronto, Canada
Brian Levine*
Affiliation:
Rotman Research Institute, Baycrest, Toronto, Canada Department of Psychology, University of Toronto, Canada Department of Medicine (Neurology), University of Toronto, Canada
*
Correspondence and reprint requests addressed to: Brian Levine, Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, ON, M6A 2E1. E-mail: blevine@research.baycrest.org
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Abstract

Traumatic brain injury (TBI) is associated with long-term changes in daily life functioning, yet the neuroanatomical correlates of these changes are poorly understood. This study related outcome assessed across several domains to brain structure derived from quantitative magnetic resonance imaging (MRI). Sixty individuals spanning a wide range of TBI severity participated 1-year post-injury as part of the Toronto TBI study. Volumetric data over 38 brain regions were derived from high resolution T1-weighted MRI scans. Functioning was assessed with a battery of self- and significant-other rated measures. Multivariate analysis (partial least squares) was used to identify shared variance between the neuroimaging and outcome measures. TBI was associated with item endorsement on outcome questionnaires without strong evidence for severity or focal lesion effects. Prefrontal midline, cingulate, medial temporal, right inferior parietal and basal ganglia/thalamic volumes were associated with measures of initiative, energization, and physical complaints. In the chronic stage of TBI, self-initiation, energization, and physical complaints related to a specific pattern of volume loss in midline and lateral regions known to be involved in motivation, apathy, and attention. These results suggest that crucial functional changes in chronic TBI may be associated with volume loss in established midline-frontal and attentional circuits. (JINS, 2015, 21, 650–655)

Keywords

PsychologyPsychosocial aspectsMotivationCraniocerebral traumaDiffuse axonal injuryMagnetic resonance imaging
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 8 , September 2015 , pp. 650 - 655
Copyright
Copyright © The International Neuropsychological Society 2015 

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