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Longitudinal Associations among Posttraumatic Stress Disorder Symptoms, Traumatic Brain Injury, and Neurocognitive Functioning in Army Soldiers Deployed to the Iraq War

Published online by Cambridge University Press:  04 December 2017

Jennifer J. Vasterling ,
Mihaela Aslan ,
Lewina O. Lee ,
Susan P. Proctor ,
John Ko ,
Shawna Jacob  and
John Concato
Jennifer J. Vasterling*
Affiliation:
National Center for PTSD and Psychology Service, VA Boston Healthcare System, Boston, Massachusetts Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts
Mihaela Aslan
Affiliation:
Clinical Epidemiology Research Center, VA Cooperative Studies Program, West Haven, Connecticut Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
Lewina O. Lee
Affiliation:
Department of Psychiatry, Boston University School of Medicine, Boston, Massachusetts Research Service, VA Boston Healthcare System, Boston, Massachusetts
Susan P. Proctor
Affiliation:
Research Service, VA Boston Healthcare System, Boston, Massachusetts US Army Research Institute of Environmental Medicine, Natick, Massachusetts Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts
John Ko
Affiliation:
Clinical Epidemiology Research Center, VA Cooperative Studies Program, West Haven, Connecticut
Shawna Jacob
Affiliation:
Psychology Service, VA Boston Healthcare System, Boston, Massachusetts
John Concato
Affiliation:
Clinical Epidemiology Research Center, VA Cooperative Studies Program, West Haven, Connecticut Department of Medicine, Yale University School of Medicine, New Haven, Connecticut
*
Correspondence and reprint requests to: Jennifer J. Vasterling, Psychology (116B), VA Boston Healthcare System, 150 S. Huntington Avenue, Boston, MA 02130. E-mail: jennifer.vasterling@va.gov
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Abstract

Objectives: Military deployment is associated with increased risk of adverse emotional and cognitive outcomes. Longitudinal associations involving posttraumatic stress disorder (PTSD), relatively mild traumatic brain injury (TBI), and neurocognitive compromise are poorly understood, especially with regard to long-term outcomes, and rigorous research is necessary to better understand the corresponding relationships. The objective of this study was to examine short-term and long-term (>5 years) longitudinal associations among PTSD, neurocognitive performance, and TBI following military deployment. Methods: In this prospective study, N=315 U.S. Army soldiers were assessed at military installations before (2003–2005) and after (2004–2006) an index deployment to the Iraq War, and again an average of 7.6 years later (2010–2014) as a nationally dispersed cohort of active duty soldiers, reservists, and veterans. Thus, the study design allowed for two measurement intervals over which to examine changes. All assessments included the PTSD Checklist, civilian version, and individually-administered performance-based neurocognitive tests. TBI history was derived from clinical interview. Results: Autoregressive analyses indicated that visual reproduction scores were inversely related to subsequent PTSD symptom severity at subsequent assessments. Conversely, increases in PTSD symptom severity over each measurement interval were associated with poorer verbal and/or visual recall at the end of each interval, and less efficient reaction time at post-deployment. TBI, primarily mild in this sample, was associated with adverse PTSD symptom outcomes at both post-deployment and long-term follow-up. Conclusions: These results suggest longitudinal relationships among PTSD symptoms, TBI, and neurocognitive decrements may contribute to sustained emotional and neurocognitive symptoms over time. (JINS, 2018, 24, 311–323)

Keywords

Cognitive functionPosttraumatic stress disordersMilitary personnelVeteransTraumatic brain injuryWar exposure
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 24 , Issue 4 , April 2018 , pp. 311 - 323
Copyright
Copyright © The International Neuropsychological Society 2017 

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