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Mood disturbance versus other symptoms of depression in multiple sclerosis

Published online by Cambridge University Press:  26 February 2009

David L. Nyenhuis ,
Stephen M. Rao ,
John M. Zajecka ,
Tracy Luchetta ,
Linda Bernardin  and
David C. Garron
David L. Nyenhuis
Affiliation:
Department of Psychology and Social Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612
Stephen M. Rao
Affiliation:
Neuropsychology Section, Neurology Department, Medical College of Wisconsin, Milwaukee, WI 53226
John M. Zajecka
Affiliation:
Psychiatry Department, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612
Tracy Luchetta
Affiliation:
Human Development Unit, University of Wisconsin-Green Bay, Green Bay, Wl 54711
Linda Bernardin
Affiliation:
Neuropsychology Section, Neurology Department, Medical College of Wisconsin, Milwaukee, WI 53226
David C. Garron
Affiliation:
Department of Psychology and Social Sciences, Rush-Presbyterian-St. Luke's Medical Center, Chicago, IL 60612
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Abstract

We administered the Multiscale Depression Inventory (MDI) and the Beck Depression Inventory (BDI) to 84 multiple sclerosis (MS) patients, 101 patients diagnosed with major depression and 87 nonmedical, nonpsychiatric controls. The MDI consists of three separate depression scales measuring mood, vegetative, and evaluative symptoms. We found that: (a) MS patients did not significantly differ from the controls in mood symptoms, (b) the depression prevalence rate in MS patients was significantly lower when measured by the mood scale (17·7%) than by the BDI (30·5%) or MDI total score (26·6%), and (c) MS patients showed significantly less mood disturbance than a non-MS comparison group matched on BDI measured depression severity. We suggest that the inclusion of nonmood symptoms in self-report depression scales may artificially raise both prevalence rates and severity ratings of MS related depression and that the most valid measure of depression in MS is mood disturbance. (JINS, 1995, I, 291–296.)

Keywords

DepressionAssessmentMultiple SclerosisMood
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 1 , Issue 3 , May 1995 , pp. 291 - 296
Copyright
Copyright © The International Neuropsychological Society 1995

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