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Neural Underpinnings of Working Memory in Adult Survivors of Childhood Brain Tumors

Published online by Cambridge University Press:  03 August 2015

Tricia Z. King ,
Sabrina Na  and
Hui Mao
Tricia Z. King*
Affiliation:
Department of Psychology and Neuroscience Institute, Georgia State University
Sabrina Na
Affiliation:
Department of Psychology and Neuroscience Institute, Georgia State University
Hui Mao
Affiliation:
Department of Radiology and Imaging Sciences, Emory University
*
Correspondence and reprint requests to: Tricia Z. King, Georgia State University Department of Psychology, P.O. Box 5010, Atlanta, GA 30302-5010. E-mail: tzking@gsu.edu
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Abstract

Adult survivors of childhood brain tumors are at risk for cognitive performance deficits that require the core cognitive skill of working memory. Our goal was to examine the neural mechanisms underlying working memory performance in survivors. We studied the working memory of adult survivors of pediatric posterior fossa brain tumors using a letter n-back paradigm with varying cognitive workload (0-, 1-, 2-, and 3-back) and functional magnetic resonance imaging as well as neuropsychological measures. Survivors of childhood brain tumors evidenced lower working memory performance than demographically matched healthy controls. Whole-brain analyses revealed significantly greater blood-oxygen level dependent (BOLD) activation in the left superior / middle frontal gyri and left parietal lobe during working memory (2-back versus 0-back contrast) in survivors. Left frontal BOLD response negatively correlated with 2- and 3-back working memory performance, Auditory Consonant Trigrams (ACT), and Digit Span Backwards. In contrast, parietal lobe BOLD response negatively correlated with 0-back (vigilance task) and ACT. The results revealed that adult survivors of childhood posterior fossa brain tumors recruited additional cognitive control resources in the prefrontal lobe during increased working memory demands. This increased prefrontal activation is associated with lower working memory performance and is consistent with the allocation of latent resources theory. (JINS, 2015, 21, 494–505)

Keywords

NeuroimagingExecutive functionPosterior fossaNeoplasmn-backPediatric
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 7 , August 2015 , pp. 494 - 505
Copyright
Copyright © The International Neuropsychological Society 2015 

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