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Neuropsychological and psychiatric functioning pre- and posthematopoietic stem cell transplantation in adult cancer patients: A preliminary study

Published online by Cambridge University Press:  13 December 2006

LEIGH J. BEGLINGER ,
KEVIN DUFF ,
SARA VAN DER HEIDEN ,
DAVID J. MOSER ,
JOHN D. BAYLESS ,
JANE S. PAULSEN  and
ROGER GINGRICH
LEIGH J. BEGLINGER
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
KEVIN DUFF
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
SARA VAN DER HEIDEN
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
DAVID J. MOSER
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
JOHN D. BAYLESS
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
JANE S. PAULSEN
Affiliation:
Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa
ROGER GINGRICH
Affiliation:
Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa
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Abstract

The current study characterizes cognitive and psychiatric status in hematopoietic stem cell transplantation (HSCT) patients shortly before and after transplant. Thirty adult patients were assessed prospectively 1–2 weeks before transplantation and 100 days posttransplantation on neuropsychological and psychiatric measures. Before transplant, participants showed mild impairments on several neuropsychological measures, with the poorest performances occurring on learning and attention. Psychiatric functioning was significantly elevated compared with normative data. Significant improvements, however, were observed on neuropsychological measures by 100 days after transplant. Depression and anxiety scores also improved. Candidates for HSCT experienced mild diffuse cognitive dysfunction and psychiatric morbidity before the procedure, but these symptoms significantly improved by 3 months following their transplant in this small sample. Education about these possible pretransplant sequelae and the potential for rebound may be helpful to patients and families as they prepare for this treatment and the recovery period (JINS, 2007, 13, 172–177.)

Keywords

Bone marrow transplantationCognitionCancerAttentionRecoveryDepressionAnxietyPractice effects
Type
BRIEF COMMUNICATIONS
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 1 , January 2007 , pp. 172 - 177
Copyright
© 2007 The International Neuropsychological Society

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