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Normative Data for the ELSA-Brasil Neuropsychological Assessment and Operationalized Criterion for Cognitive Impairment for Middle-Aged and Older Adults

Published online by Cambridge University Press:  14 October 2020

Laiss Bertola Open the ORCID record for Laiss Bertola [Opens in a new window] ,
Isabela M. Benseñor ,
Alessandra C. Goulart ,
Andre R. Brunoni ,
Paulo Caramelli ,
Sandhi Maria Barreto ,
Luana Giatti ,
Larissa Salvador ,
Rosane Harter Griep  and
Arlinda B. Moreno
...Show all authors
Laiss Bertola*
Affiliation:
University of São Paulo Medical School, Av. Dr. Arnaldo, 455 – Cerqueira César, São Paulo, SP01246-903, Brazil
Isabela M. Benseñor
Affiliation:
Epidemiological and Clinical Research Center, University Hospital, University of São Paulo, São Paulo, SP01246-903, Brazil Department of Internal Medicine, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 – Cerqueira César, São Paulo, SP01246-903, Brazil
Alessandra C. Goulart
Affiliation:
Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo, São Paulo, SP01246-903, Brazil
Andre R. Brunoni
Affiliation:
Department of Internal Medicine, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP01246-903, Brazil Laboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP01246-903, Brazil Center for Clinical and Epidemiological Research, Hospital Universitário, Universidade de São Paulo, São Paulo, SP01246-903, Brazil
Paulo Caramelli
Affiliation:
Departamento de Clínica Médica, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG30130-100, Brazil. E-mail: caramelli@ufmg.br
Sandhi Maria Barreto
Affiliation:
Medical School & Clinical Hospital. Federal University of Minas Gerais, Av. Prof. Alfredo Balena, 190 – Santa Efigênia, Belo Horizonte, MG30130-100, Brazil
Luana Giatti
Affiliation:
Departamento de Medicina Preventiva e Social da Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), Av. Prof. Alfredo Balena, 190 – Santa Efigênia, Belo Horizonte, MG30130-100, Brazil
Larissa Salvador
Affiliation:
Programa de Pós-Graduação em Ciências Aplicadas à Saúde do Adulto/Faculdade de Medicina, UFMG, Belo Horizonte, MG30130-310, Brazil
Rosane Harter Griep
Affiliation:
Laboratory of Health and Environment Education, Oswaldo Cruz Institute, Rio de Janeiro, RJ21040-360, Brazil
Arlinda B. Moreno
Affiliation:
Department of Epidemiology and Quantitative Methods in Health, Sergio Arouca National School of Public Health, Oswaldo Cruz Foundation, Rio de Janeiro, RJ21040-360, Brazil
Paulo A. Lotufo
Affiliation:
Epidemiological and Clinical Research Center, University Hospital, University of São Paulo, São Paulo, SP01246-903, Brazil Department of Internal Medicine, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 – Cerqueira César, São Paulo, SP01246-903, Brazil
Claudia K. Suemoto
Affiliation:
Division of Geriatrics, University of Sao Paulo Medical School, Av. Dr. Arnaldo, 455 – Cerqueira César, São Paulo, SP01246-903, Brazil E-mail: cksuemoto@usp.br
*
*Correspondence and reprint requests to: Laiss Bertola, University of São Paulo Medical School, Av. Dr. Arnaldo, 455 – Cerqueira César, São Paulo, SP01246-903, Brazil. E-mail: laissbertola@gmail.com
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Abstract

Objectives:

Normative data should consider sociodemographic diversity for the accurate diagnosis of cognitive impairment. This study aims to provide normative data for a brief neuropsychological battery and present diagnostic criteria for cognitive impairment that could be used in primary care settings.

Methods:

We selected 9618 Brazilian middle-aged and older adults after detailed exclusion criteria to avoid subtle cognitive impairment. We analyzed age, sex, and education influence on cognitive performance. To verify the evidence of criterion validity, we compared the cognitive performance of subjects with and without a depressive episode. Additionally, we verified the percentage of spurious scores under three different cutoffs.

Results:

Age and education had the greatest impact on cognition. Normative scores were provided according to age and education groups. Participants with a depressive episode performed poorer than control subjects. The clinical cutoff of at least two scores below the 7th percentile revealed the adequate percentage of spurious and possible clinical performance.

Conclusions:

The Longitudinal Study on Adult Health (ELSA-Brasil) provided normative data based on a unique selected set of cognitively normal subjects. Normative groups were selected based on age and education, and the battery was sensitive to the presence of a depressive episode. We suggested clinical cutoffs for the tests in this battery that could be used in primary care settings to improve the accurate diagnosis of cognitive impairment.

Keywords

Cognitive batteryEpisodic memoryExecutive functionNormal agingImpairmentNormative data
Type
Regular Research
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 3 , March 2021 , pp. 293 - 303
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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