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Performance of the NINDS-CSN 5-Minute Protocol in a National Population-Based Sample

Published online by Cambridge University Press:  27 August 2014

Richard E. Kennedy ,
Virginia G. Wadley ,
Leslie A. McClure ,
Abraham J. Letter ,
Frederick W. Unverzagt ,
Michael Crowe ,
David Nyenhius ,
Brendan J. Kelley ,
Bhumika Kana  and
Janice Marceaux
...Show all authors
Richard E. Kennedy*
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Virginia G. Wadley
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Leslie A. McClure
Affiliation:
Department of Biostatistics, University of Alabama Birmingham, Birmingham, Alabama
Abraham J. Letter
Affiliation:
WL Gore and Associates, Flagstaff, Arizona
Frederick W. Unverzagt
Affiliation:
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana
Michael Crowe
Affiliation:
Department of Psychology, University of Alabama Birmingham, Birmingham, Alabama
David Nyenhius
Affiliation:
Hauenstein Neuroscience Center, Mercy Health Saint Mary’s, Grand Rapids, Michigan
Brendan J. Kelley
Affiliation:
Department of Neurology, Ohio State University, Columbus, Ohio
Bhumika Kana
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
Janice Marceaux
Affiliation:
Department of Psychology, University of Alabama Birmingham, Birmingham, Alabama
Manjula Kurella Tamura
Affiliation:
Department of Medicine, Stanford University, Stanford, California
Virginia Howard
Affiliation:
Department of Epidemiology, University of Alabama Birmingham, Birmingham, Alabama
George Howard
Affiliation:
Department of Medicine, University of Alabama Birmingham, Birmingham, Alabama
*
Correspondence and reprint requests to: Richard E. Kennedy, Division of Gerontology, Geriatrics, and Palliative Care, Department of Medicine, University of Alabama at Birmingham, 933 19th Street South, CH19-218R, Birmingham, AL. E-mail: rekenned@uab.edu
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Abstract

In 2006, the National Institute of Neurological Disorders and Stroke-Canadian Stroke Network (NINDS-CSN) Vascular Cognitive Impairment Harmonization Standards recommended a 5-Minute Protocol as a brief screening instrument for vascular cognitive impairment (VCI). We report demographically adjusted norms for the 5-Minute Protocol and its relation to other measures of cognitive function and cerebrovascular risk factors. We performed a cross-sectional analysis of 7199 stroke-free adults in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study on the NINDS-CSN 5-Minute Protocol score. Total scores on the 5-Minute Protocol were inversely correlated with age and positively correlated with years of education, and performance on the Six-Item Screener, Word List Learning, and Animal Fluency (all p-values <.001). Higher cerebrovascular risk on the Framingham Stroke Risk Profile (FSRP) was associated with lower total 5-Minute Protocol scores (p <.001). The 5-Minute Protocol also differentiated between participants with and without confirmed stroke and with and without stroke symptom histories (p <.001). The NINDS-CSN 5-Minute Protocol is a brief, easily administered screening measure that is sensitive to cerebrovascular risk and offers a valid method of screening for cognitive impairment in populations at risk for VCI. (JINS, 2014, 20, 1–12)

Keywords

ScreeningCerebrovascular disordersEpidemiologyMemorySemantic fluencyDepression
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 20 , Supplement 8 , September 2014 , pp. 856 - 867
Copyright
Copyright © The International Neuropsychological Society 2014 

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