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Processing Speed and Working Memory Span: Their Differential Role in Superficial and Deep Memory Processes in Schizophrenia

Published online by Cambridge University Press:  08 March 2011

Gildas Brébion ,
Rodrigo A. Bressan ,
Lyn S. Pilowsky  and
Anthony S. David
Gildas Brébion*
Affiliation:
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom Unit of Research and Development, Sant Joan de Déu – Serveis de Salut Mental y CIBERSAM, Barcelona, Spain
Rodrigo A. Bressan
Affiliation:
Center for Neuroimaging and Cognition, University of Sao Paulo, Brazil
Lyn S. Pilowsky
Affiliation:
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom
Anthony S. David
Affiliation:
Section of Cognitive Neuropsychiatry, Institute of Psychiatry, King's College London, United Kingdom
*
Correspondence and reprint requests to: Gildas Brébion, Unit of Research and Development, Sant Joan de Déu – Serveis de Salut Mental, C\Doctor Antoni Pujadas 42, 08830 Sant Boi de Llobregat (Barcelona) Spain. E-mail: gildas.brebion@kcl.ac.uk
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Abstract

Previous work has suggested that decrement in both processing speed and working memory span plays a role in the memory impairment observed in patients with schizophrenia. We undertook a study to examine simultaneously the effect of these two factors. A sample of 49 patients with schizophrenia and 43 healthy controls underwent a battery of verbal and visual memory tasks. Superficial and deep encoding memory measures were tallied. We conducted regression analyses on the various memory measures, using processing speed and working memory span as independent variables. In the patient group, processing speed was a significant predictor of superficial and deep memory measures in verbal and visual memory. Working memory span was an additional significant predictor of the deep memory measures only. Regression analyses involving all participants revealed that the effect of diagnosis on all the deep encoding memory measures was reduced to non-significance when processing speed was entered in the regression. Decreased processing speed is involved in verbal and visual memory deficit in patients, whether the task require superficial or deep encoding. Working memory is involved only insofar as the task requires a certain amount of effort. (JINS, 2011, 17, 485–493)

Keywords

Semantic memoryLearningLanguagePicturesCognitive symptomsLevel of processing
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 3 , May 2011 , pp. 485 - 493
Copyright
Copyright © The International Neuropsychological Society 2011

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References

REFERENCES

Aleman, A., Hijman, R., de Haan, E.H.F., Kahn, R.S. (1999). Memory impairment in schizophrenia: A meta analysis. The American Journal of Psychiatry, 156, 1358–1366.CrossRefGoogle ScholarPubMed
Baddeley, A. (1986). Working memory. Oxford: Clarendon Press.Google Scholar
Battig, W.F., Montague, W.E. (1969). Category norms for verbal items in 56 categories: A replication and extension of the Connecticut category norms. Journal of Experimental Psychology (Monograph), 80(3 Pt 2), 1–46.CrossRefGoogle Scholar
Brébion, G., Bressan, R.A., David, A.S., Pilowky, L.S. (2009). Role of processing speed and premorbid IQ on visual recognition in patients with schizophrenia. Journal of Clinical and Experimental Neuropsychology, 31, 302–311.CrossRefGoogle ScholarPubMed
Brébion, G., David, A.S., Bressan, R.A., Pilowsky, L.S. (2006). Processing speed: A strong predictor of verbal memory performance in schizophrenia. Journal of Clinical and Experimental Neuropsychology, 28, 370–382.CrossRefGoogle Scholar
Brébion, G., David, A.S., Bressan, R.A., Pilowsky, L.S. (2007). Role of processing speed and depressed mood on encoding, storage, and retrieval memory functions in patients diagnosed with schizophrenia. Journal of the International Neuropsychological Society, 13, 99–107.CrossRefGoogle ScholarPubMed
Brébion, G., Gorman, J., Malaspina, D., Sharif, Z., Amador, X. (2001). Clinical and cognitive factors associated with verbal memory task performance in patients with schizophrenia. The American Journal of Psychiatry, 158, 758–764.Google Scholar
Brébion, G., Smith, M., Gorman, J., Malaspina, D., Sharif, Z., Amador, X. (2000). Memory and schizophrenia: Differential link of processing speed and selective attention with two levels of encoding. Journal of Psychiatric Research, 34, 121–127.CrossRefGoogle ScholarPubMed
Cirillo, M.A., Seidman, L.J. (2003). Verbal declarative memory dysfunction in schizophrenia: From clinical assessment to genetics and brain mechanisms. Neuropsychology Review, 13, 43–77.CrossRefGoogle ScholarPubMed
Conklin, H.M., Curtis, C.E., Katsanis, J., Iacono, W.G. (2000). Verbal working memory impairment in schizophrenia patients and their first-degree relatives: Evidence from the Digit Span task. The American Journal of Psychiatry, 157, 275–277.CrossRefGoogle ScholarPubMed
Corwin, J. (1994). On measuring discrimination and response bias: Unequal numbers of targets and distractors and two classes of distractors. Neuropsychology, 8, 110–117.CrossRefGoogle Scholar
Craik, F.I.M. (2002). Levels of processing: Past, present… and future? Memory, 10, 305–318.Google Scholar
Dickinson, D., Ramsey, M.E., Gold, J.M. (2007). Overlooking the obvious. A meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia. Archives of General Psychiatry, 64, 532–542.CrossRefGoogle ScholarPubMed
Forbes, N.F., Carrick, L.A., McIntosh, A.M., Lawrie, S.M. (2009). Working memory in schizophrenia: A meta-analysis. Psychological Medicine, 39, 889–905.CrossRefGoogle ScholarPubMed
Fuller, R.L., Luck, S.J., Braun, E.L., Robinson, B.M., McMahon, R.P., Gold, J.M. (2009). Impaired visual working memory consolidation in schizophrenia. Neuropsychology, 23, 71–80.CrossRefGoogle ScholarPubMed
Green, M.F. (1996). What are the functional consequences of neurocognitive deficits in schizophrenia? The American Journal of Psychiatry, 153, 321–330.Google ScholarPubMed
Heinrichs, R.W., Zakzanis, K.K. (1998). Neurocognitive deficit in schizophrenia: A quantitative review of the evidence. Neuropsychology, 12, 426–445.CrossRefGoogle ScholarPubMed
Holthausen, E.A.E., Wiersma, D., Sitskoorn, M.M., Dingemans, P.M., Schene, A.H., van den Bosch, R.J. (2003). Long-term memory deficits in schizophrenia: Primary or secondary dysfunction? Neuropsychology, 17, 539–547.CrossRefGoogle ScholarPubMed
Hunt, R.R., McDaniel, M.A. (1993). The enigma of organization and distinctiveness. Journal of Memory and Language, 32, 421–445.CrossRefGoogle Scholar
Knowles, E.E.M., David, A.S., Reichenberg, A. (2010). Processing speed deficits in schizophrenia: Reexamining the evidence. The American Journal of Psychiatry, 167, 828–835.Google Scholar
Kremen, W.S., Seidman, L.J., Faraone, S.V., Tsuang, M.T. (2003). Is there disproportionate impairment in semantic or phonemic fluency in schizophrenia? Journal of the International Neuropsychological Society, 9, 79–88.Google Scholar
Kucera, H., Francis, W.N. (1967). Computational analysis of present-day American English. Providence, RI: Brown University Press.Google Scholar
Lee, J., Park, S. (2005). Working memory impairments in schizophrenia: A meta-analysis. Journal of Abnormal Psychology, 114, 599–611.Google Scholar
Leeson, V.C., Barnes, T.R.E., Harrison, M., Matheson, E., Harrison, I., Mutsatsa, S.H., Joyce, E.M. (2010). The relationship between IQ, memory, executive function, and processing speed in recent-onset psychosis: 1-year stability and clinical outcome. Schizophrenia Bulletin, 36, 400–409.Google Scholar
Levaux, M.-N., Vezzaro, J., Larøi, F., Offerlin-Meyer, I., Danion, J.-M., Van der Linden, M. (2009). Cognitive rehabilitation of the updating sub-component of working memory in schizophrenia: A case study. Neuropsychological Rehabilitation, 19, 244–273.CrossRefGoogle ScholarPubMed
Malmberg, K.J., Nelson, T.O. (2003). The word frequency effect for recognition memory and the elevated-attention hypothesis. Memory & Cognition, 31, 35–43.CrossRefGoogle ScholarPubMed
Mesholam-Gately, R.I., Giuliano, A.J., Goff, K.P., Faraone, S.V., Seidman, L.J. (2009). Neurocognition in first-episode schizophrenia: A meta-analytic review. Neuropsychology, 23, 315–336.Google Scholar
Morrens, M., Hulstijn, W., Sabbe, B. (2007). Psychomotor slowing in schizophrenia. Schizophrenia Bulletin, 33, 1038–1053.CrossRefGoogle ScholarPubMed
Morrens, M., Hulstijn, W., Van Hecke, J., Peuskens, J., Sabbe, B.G.C. (2006). Sensorimotor and cognitive slowing in schizophrenia as measured by the Symbol Digit Substitution Test. Journal of Psychiatric Research, 40, 200–206.CrossRefGoogle ScholarPubMed
Nebes, R.D., Butters, M.A., Mulsant, B.H., Pollock, B.G., Zmuda, M.D., Houck, P.R., Reynolds, C.F. (2000). Decreased working memory and processing speed mediate cognitive impairment in geriatric depression. Psychological Medicine, 30, 679–691.CrossRefGoogle ScholarPubMed
Nuechterlein, K.H., Barch, D.M., Gold, J.M., Goldberg, T.E., Green, M.F., Heaton, R.K. (2004). Identification of separable cognitive factors in schizophrenia. Schizophrenia Research, 72, 29–39.CrossRefGoogle ScholarPubMed
Ojeda, N., Peña, J., Sánchez, P., Elizagárate, E., Escurra, J. (2008). Processing speed mediates the relationship between verbal memory, verbal fluency, and functional outcome in chronic schizophrenia. Schizophrenia Research, 101, 225–233.Google Scholar
Ojeda, N., Sánchez, P., Peña, J., Elizagárate, E., Yoller, A.B., Larumbe, J., Ezcurra, J. (2010). Verbal fluency in schizophrenia. Does cognitive performance reflect the same underlying mechanisms in patients and healthy controls? Journal of Nervous and Mental Disease, 198, 286–291.Google Scholar
Rodriguez-Sanchez, J.M., Crespo-Facorro, B., Gonzalez-Blanch, C., Perez-Iglesias, R., Vazquez-Barquero, J.L. (2007). Cognitive dysfunction in first-episode psychosis: The processing speed hypothesis. British Journal of Psychiatry, 191, s107–s110.CrossRefGoogle Scholar
Salthouse, T.A. (1992). Mechanisms of age-cognition relations in adulthood. Hillsdale, NJ: Erlbaum.Google Scholar
Sánchez, P., Ojeda, N., Peña, J., Elizagárate, E., Yoller, A.B., Gutiérrez, M., Escurra, J. (2009). Predictors of longitudinal changes in schizophrenia: The role of processing speed. The Journal of Clinical Psychiatry, 70, 888–896.CrossRefGoogle ScholarPubMed
Sanfilipo, M., Lafargue, T., Rusinek, H., Arena, L., Loneragan, C., Lautin, A., Wolkin, A. (2002). Cognitive performance in schizophrenia: Relationship to regional brain volumes and psychiatric symptoms. Psychiatry Research: Neuroimaging, 116, 1–23.CrossRefGoogle ScholarPubMed
Silver, H., Feldman, P., Bilker, W., Gur, R.C. (2003). Working memory deficit as a core neuropsychological dysfunction in schizophrenia. The American Journal of Psychiatry, 160, 1809–1816.Google Scholar
Silver, H., Goodman, C. (2008). Verbal as well as spatial working memory predicts visuospatial processing in male schizophrenia patients. Schizophrenia Research, 101, 210–217.Google Scholar
Stone, M., Gabrieli, J.D.E., Stebbins, G.T., Sullivan, E.V. (1998). Working and strategic memory deficits in schizophrenia. Neuropsychology, 12, 278–288.CrossRefGoogle ScholarPubMed
van Beilen, M., Pijnenborg, M., van Zomeren, E.H., van den Bosch, R.J., Withaar, F.K., Bouma, A. (2004). What is measured by verbal fluency tests in schizophrenia? Schizophrenia Research, 69, 267–276.CrossRefGoogle ScholarPubMed
Wichmann, F.A., Sharpe, L.T., Gegenfurtner, K.R. (2002). The contributions of color to recognition memory for natural scenes. Journal of Experimental Psychology: Learning, Memory, & Cognition, 28, 509–520.Google Scholar