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Prodromal frontal/executive dysfunction predicts incident dementia in Parkinson’s disease

Published online by Cambridge University Press:  13 January 2003

Steven Paulwoods  and
Alexander I. Tröster
Steven Paulwoods
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington
Alexander I. Tröster
Affiliation:
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington Department of Neurological Surgery, University of Washington School of Medicine, Seattle, Washington
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Abstract

To identify the cognitive characteristics predictive of incident dementia in Parkinson’s disease (PD), we examined the baseline neuropsychological profiles of 18 initially non-demented patients with PD who met diagnostic criteria for dementia (PDD) at one-year follow-up. PDD participants’ baseline neuropsychological test scores were compared to the baseline performance of 18 patients with PD who did not meet criteria for dementia at one-year follow-up (PDND) and 18 normal controls (NC). The three groups were matched on baseline demographic and disease variables. Relative to the PDND group, the incident PDD participants demonstrated significantly poorer performance on digits backward (Wechsler Memory Scale–Revised), word list learning and recognition (California Verbal Learning Test), and perseverative errors on the Wisconsin Card Sorting Test. Each of these baseline neuropsychological variables exhibited adequate diagnostic classification accuracy in predicting PDD and PDND group membership at follow-up. These results suggest that subtle frontal0executive dysfunction is evident during the immediate PDD prodrome and may be of prognostic value in identifying PD patients at risk for dementia. Accordingly, neuropsychological evaluation may facilitate early identification of PDD and thereby inform appropriate dispositional planning. (JINS, 2003, 9, 17–24.)

Keywords

Parkinson’s diseaseDementiaExecutive functionFrontal lobe
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 9 , Issue 1 , January 2003 , pp. 17 - 24
Copyright
Copyright © The International Neuropsychological Society 2003

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References

Aarsland, D., Larsen, J.P., Karlsen, K., Lim, N.G., & Tandberg, E. (1999). Mental symptoms in Parkinson's disease are important contributors to caregiver distress. International Journal of Geriatric Psychiatry, 14, 866–874.10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z3.0.CO;2-Z' href=https://dx.doi.org/10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z>CrossRef3.0.CO;2-Z' href=https://scholar.google.com/scholar?q=Aarsland,+D.,+Larsen,+J.P.,+Karlsen,+K.,+Lim,+N.G.,+&+Tandberg,+E.+(1999).+Mental+symptoms+in+Parkinson's+disease+are+important+contributors+to+caregiver+distress.+International+Journal+of+Geriatric+Psychiatry,+14,+866–874.10.1002/(SICI)1099-1166(199910)14:10<866::AID-GPS38>3.0.CO;2-Z>Google Scholar
Aarsland, D., Larsen, J.P., Tandberg, E., & Laake, K. (2000). Predictors of nursing home placement in Parkinson's disease: A population-based, prospective study. Journal of the American Geriatric Society, 48, 938–942.10.1111/j.1532-5415.2000.tb06891.xCrossRefGoogle Scholar
Baldessarini, E.J., Finklestein, S., & Arana, G.W. (1983). The predictive power of diagnostic tests and the effect of prevalence of illness. Archives of General Psychiatry, 40, 569–573.10.1001/archpsyc.1983.01790050095011CrossRefGoogle Scholar
Beck, A.T. (1992). Beck depression inventory. Manual. San Antonio TX: Psychological Corporation.Google Scholar
Benton, A.L., Hamsher, K., & Sivan, A.B. (1994). Multilingual aphasia examination (3rd ed.). Iowa City, IA: AJA Associates.Google Scholar
Biggins, C.A., Boyd, J.L., Harrop, F.M., Madeley, P., Mindham, R.H.S., Randall, J.I., & Spokes, E.G.S. (1992). A controlled, longitudinal study of dementia in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 55, 566–571.10.1136/jnnp.55.7.566CrossRefGoogle Scholar
Blair, J.R. & Spreen, O. (1989). Predicting premorbid IQ: A revision of the national adult reading test. The Clinical Neuropsychologist, 3, 129–136.10.1080/13854048908403285CrossRefGoogle Scholar
Buytenhuijs, E.L., Berger, H.J.C., VanSpaendonck, K.P.M., Horstink, W.I.M., Borm, G.F., & Cools, A.R. (1994). Memory and learning strategies in patients with Parkinson's disease. Neuropsychologia, 32, 335–342.10.1016/0028-3932(94)90135-XCrossRefGoogle Scholar
Cummings, J.L. & Benson, D.F. (1983). Dementia: A clinical approach. Boston: Butterworths.Google Scholar
Delis, D.C., Kramer, J.H., Kaplan, E., & Ober, B.A. (1987). California verbal learning test: Adult version. San Antonio, TX: The Psychological Corporation.Google Scholar
Dubois, B. & Pillon, B. (1998). Cognitive and behavioral aspects of movement disorders. In J. Jankovic & E. Tolosa (Eds.), Parkinson's disease and movement disorders (3rd ed.). (pp. 837–858). Baltimore, MD: Williams & Wilkins.Google Scholar
Fahn, S., Elton, R.L., & Members of the UPDRS Development Committee. (1987). The Unified Parkinson's Disease Rating Scale. In: S. Fahn, S.D. Marden, D.B. Calne, & M. Goldstein (Eds.), Recent developments in Parkinson's disease, Vol. 2 (pp. 153–163). Florham Park, NJ: Macmillan Healthcare.Google Scholar
Fields, J.A. & Tröster, A.I. (2000). Cognitive outcomes after deep brain stimulation for Parkinson's disease: A review of initial studies and recommendations for future research. Brain and Cognition, 42, 268–293.10.1006/brcg.1999.1104CrossRefGoogle Scholar
Filoteo, J.V., Rilling, L.M., Cole, B., Williams, B.J., Davis, J.D., & Roberts, J.W. (1997). Variable memory profiles in Parkinson's disease. Journal of Clinical and Experimental Neuropsychology, 19, 878–888.10.1080/01688639708403768CrossRefGoogle Scholar
Fletcher, P.C. & Henson, R.N. (2001). Frontal lobes and human memory: Insights from functional neuroimaging. Brain, 124, 849–881.10.1093/brain/124.5.849CrossRefGoogle Scholar
Glatt, S.L., Hubble, J.P., Lyons, K., Paolo, A., Tröster, A.I., Hassanein, R.E.S., & Koller, W.C. (1996). Risk factors for dementia in Parkinson's disease: Effect of education. Neuroepidemiology, 15, 20–25.10.1159/000109885CrossRefGoogle Scholar
Heaton, R.K., Chelune, G.J., Talley, J.L., Kay, G.G., & Curtis, G. (1993). Wisconsin card sorting test manual—revised and expanded. Odessa, FL: Psychological Assessment Resources.Google Scholar
Hughes, T.A., Ross, H.F., Musa, S., Bhattacherjee, S., Nathan, R.N., Mindham, R.H.S., & Spokes, E.G.S. (2000). A 10-year study of the incidence of and factors predicting dementia in Parkinson's disease. Neurology, 54, 1596–1602.10.1212/WNL.54.8.1596CrossRefGoogle Scholar
Jacobs, D.M., Marder, K., Cote, L.J., Sano, M., Stern, Y., & Mayeux, R. (1995a). Neuropsychological characteristics of preclinical dementia in Parkinson's disease. Neurology, 45, 1691–1696.10.1212/WNL.45.9.1691CrossRefGoogle Scholar
Jacobs, D.M., Sano, M., Dooneief, G., Marder, K., Bell, K.L., & Stern, Y. (1995b). Neuropsychological detection and characterization of preclinical Alzheimer's disease. Neurology, 45, 957–962.10.1212/WNL.45.5.957CrossRefGoogle Scholar
Jacobs, D.M., Stern, Y., & Mayeux, R. (2000). Dementia in Parkinson's disease, Huntington's disease, and other degenerative conditions. In M.J. Farah & T.E. Feinberg (Eds.), Patient-based approaches to cognitive neuroscience (pp. 375–384). Cambridge, MA: MIT Press.Google Scholar
Johnson, S.C., Saykin, A.J., Flashman, L.A., McAllister, T.W., & Sparling, M.B. (2001). Brain activation on fMRI and verbal memory ability: Functional neuroanatomic correlates of CVLT performance. Journal of the International Neuropsychological Society, 7, 55–62.10.1017/S135561770171106XCrossRefGoogle Scholar
Kaplan, E., Goodglass, H., & Weintraub, S. (1983). Boston naming test. Philadelphia: Lea & Febiger.Google Scholar
Lombardi, W.J., Andreason, P.J., Sirocco, K.Y., Rio, D.E., Gross, R.E., Umhau, J.C., & Hommer, D.W. (1999). Wisconsin card sorting test performance following head injury: Dorsolateral fronto-striatal circuit activity predicts perseveration. Journal of Clinical and Experimental Neuropsychology, 21, 2–16.10.1076/jcen.21.1.2.940CrossRefGoogle Scholar
Luria, A.R. (1966). Higher cortical functions in man. London: Tavistock.Google Scholar
Mahieux, F., Fenelon, G., Flahault, A., Manifacier, M.J., Michelet, D., & Boller, F. (1998). Neuropsychological prediction of dementia in Parkinson's disease. Journal of Neurology, Neurosurgery, and Psychiatry, 64, 178–183.10.1136/jnnp.64.2.178CrossRefGoogle Scholar
Marder, K., Leung, D., Tang, M., Bell, K., Dooneief, G., Cote, L., Stern, Y., & Mayeux, R. (1991). Are demented patients with Parkinson's disease accurately reflected in prevalence surveys? A survival analysis. Neurology, 41, 1240–1243.10.1212/WNL.41.8.1240CrossRefGoogle Scholar
Marder, K., Tang, M.X., Cote, L., Stern, Y., & Mayeux, R. (1995). The frequency and associated risk factors for dementia in patients with Parkinson's disease. Archives of Neurology, 52, 695–701.10.1001/archneur.1995.00540310069018CrossRefGoogle Scholar
Martinez-Martin, P., Gil-Nagel, A., Gracia, L.M., Gomez, J.B., Martinez-Sarries, J., & Bermejo, F. (1994). Unified Parkinson's Disease Rating Scale characteristics and structure. The Cooperative Multicentric Group. Movement Disorders, 9, 76–83.10.1002/mds.870090112CrossRefGoogle Scholar
Mattis, S. (1988). Dementia rating scale: Professional manual. Odessa FL: Psychological Assessment Resources.Google Scholar
Mayeux, R., Chen, J., Mirabello, E., Marder, K., Bell, K., Dooneief, G., Cote, L., & Stern, Y. (1990). An estimate of the incidence of dementia in idiopathic Parkinson's disease. Neurology, 40, 1513–1517.10.1212/WNL.40.10.1513CrossRefGoogle Scholar
Middleton, F.A. & Strick, P.L. (1996). The temporal lobe is a target of output from the basal ganglia. Proceedings of the National Academy of Sciences of the United States of America, 93, 8683–8687.10.1073/pnas.93.16.8683CrossRefGoogle Scholar
Peterson, R.C., Stevens, J.C., Ganguli, M., Tangalos, E.G., Cummings, J.L., & DeKosky, S.T. (2001). Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133–1142.10.1212/WNL.56.9.1133CrossRefGoogle Scholar
Piatt, A.L., Fields, J.A., Paolo, A.M., Koller, W.C., & Tröster, A.I. (1999a). Lexical, semantic, and action verbal fluency in Parkinson's disease with and without dementia. Journal of Clinical and Experimental Neuropsychology, 21, 435–443.10.1076/jcen.21.4.435.885CrossRefGoogle Scholar
Piatt, A.L., Fields, J.A., Paolo, A.M., & Tröster, A.I. (1999b). Action (verb naming) fluency as an executive function measure: Convergent and divergent evidence of validity. Neuropsychologia, 37, 1499–1503.10.1016/S0028-3932(99)00066-4CrossRefGoogle Scholar
Piccirilli, M., D'Alessandro, P., Finali, G., Piccinin, G.L., & Agostini, L. (1989). Frontal lobe dysfunction in Parkinson's disease: Prognostic value for dementia? European Neurology, 29, 71–76.10.1159/000116381CrossRefGoogle Scholar
Ricker, J.H., Muller, R.A., Zafonte, R.D., Black, K.M., Millis, S.R., & Chugani, H. (2001). Verbal recall and recognition following traumatic brain injury: A [0-15]-water positron emission tomography study. Journal of Clinical and Experimental Neuropsychology, 23, 196–206.10.1076/jcen.23.2.196.1204CrossRefGoogle Scholar
Salganik, I. & Korczyn, A. (1990). Risk factors for dementia in Parkinson's disease. Advances in Neurology, 53, 343–347.Google Scholar
Schrag, A., Jahanshahi, M., & Quinn, N. (2000). What contributes to quality of life in patients with Parkinson's disease? Journal of Neurology, Neurosurgery, and Psychiatry, 69, 308–312.10.1136/jnnp.69.3.308CrossRefGoogle Scholar
Spreen, O. & Strauss, E. (1998). A compendium of neuropsychological tests: Administration, norms, and commentary (2nd ed.). New York: Oxford University Press.Google Scholar
Stebbins, G.T. & Goetz, C.G. (1998). Factor structure of the Unified Parkinson's Disease Rating Scale: Motor Examination section. Movement Disorders, 13, 633–636.10.1002/mds.870130404CrossRefGoogle Scholar
Stern, Y., Marder, K., Tang, M.X., & Mayeux, R. (1993a). Antecedent clinical features associated with dementia in Parkinson's disease. Neurology, 43, 1690–1692.10.1212/WNL.43.9.1690CrossRefGoogle Scholar
Stern, Y., Richards, M., Sano, M., & Mayeux, R. (1993b). Comparison of cognitive changes in patients with Alzheimer's and Parkinson's disease. Archives of Neurology, 50, 1040–1045.10.1001/archneur.1993.00540100035011CrossRefGoogle Scholar
Stuss, D.T., Alexander, M.P., Palumbo, C.L., Buckle, L., Sayer, I., & Pogue, J. (1994). Organizational strategies of patients with unilateral or bilateral frontal lobe injury on word list learning tasks. Neuropsychology, 8, 355–373.10.1037/0894-4105.8.3.355CrossRefGoogle Scholar
Testa, J.A., Tröster, A.I., Fields, J.A., Gleason, A.C., Salmon, D.P., & Beatty, W.W. (1998). Semantic fluency performance of patients with cortical and subcortical neurodegenerative diseases. Aging, Neuropsychology, and Cognition, 5, 203–214.10.1076/anec.5.3.203.612CrossRefGoogle Scholar
Tremont, G., Halpert, S., Javorsky, D., & Stern, R.A. (2000). Differential impact of executive dysfunction on verbal list learning and story recall. The Clinical Neuropsychologist, 14, 295–302.10.1076/1385-4046(200008)14:3;1-P;FT295CrossRefGoogle Scholar
Tröster, A.I. & Fields, J.A. (1995). Frontal cognitive function and memory in Parkinson's disease: Toward a distinction between prospective and declarative memory impairments. Behavioural Neurology, 8, 59–74.10.1155/1995/167286CrossRefGoogle Scholar
Tröster, A.I., Fields, J.A., Testa, J.A., Paul, R.H., Blanco, C.R., Hames, K.A., Salmon, D.P., & Beatty, W.W. (1998). Cortical and subcortical influences on clustering and switching in the performance of verbal fluency tasks. Neuropsychologia, 36, 295–304.10.1016/S0028-3932(97)00153-XCrossRefGoogle Scholar
Tröster, A.I., Fields, J.A., & Koller, W.C. (2000). Parkinson's disease and parkinsonism. In C.E. Coffey & J.L. Cummings (Eds.), The American Psychiatric Press textbook of geriatric neuropsychiatry (2nd ed.). (pp. 559–600). Washington, DC: American Psychiatric Press, Inc.Google Scholar
Vanderploeg, R.D., Schinka, J.A., & Retzlaff, P. (1994). Relationship between measures of auditory verbal learning and executive functioning. Journal of Clinical and Experimental Neuropsychology, 16, 243–252.10.1080/01688639408402635CrossRefGoogle Scholar
Wechsler, D. (1981). Wechsler adult intelligence scale–revised. San Antonio: The Psychological Corporation.Google Scholar
Wechsler, D. (1987). Wechsler memory scale–revised. Manual. San Antonio: The Psychological Corporation.Google Scholar
Zhang, Z.X., Anderson, D.W., & Mantel, N. (1990). Geographic patterns of parkinsonism-dementia complex on Guam. Archives of Neurology, 47, 1069–1074.10.1001/archneur.1990.00530100031010CrossRefGoogle Scholar