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Role of Disgust Proneness in Parkinson’s Disease: A Voxel-Based Morphometry Study

Published online by Cambridge University Press:  24 April 2015

Rottraut Ille ,
Albert Wabnegger ,
Petra Schwingenschuh ,
Petra Katschnig-Winter ,
Mariella Kögl-Wallner ,
Karoline Wenzel  and
Anne Schienle
Rottraut Ille
Affiliation:
Department of Psychology, Karl-Franzens University of Graz, Austria Department of Psychiatry, Medical University of Graz, Graz, Austria
Albert Wabnegger
Affiliation:
Department of Psychology, Karl-Franzens University of Graz, Austria
Petra Schwingenschuh
Affiliation:
Department of Neurology, Medical University of Graz, Graz, Austria
Petra Katschnig-Winter
Affiliation:
BioTechMed Graz, Austria
Mariella Kögl-Wallner
Affiliation:
Department of Neurology, Medical University of Graz, Graz, Austria
Karoline Wenzel
Affiliation:
BioTechMed Graz, Austria
Anne Schienle*
Affiliation:
Department of Psychology, Karl-Franzens University of Graz, Austria BioTechMed Graz, Austria
*
Correspondence and reprint requests to: Anne Schienle, University of Graz, Department of Psychology, Universitätsplatz 2 / III, A-8010 Graz, Austria. E-mail: anne.schienle@uni-graz.at
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Abstract

The knowledge about personality traits in Parkinson’s disease (PD) is still limited. In particular, disgust proneness has not been investigated as well as its neuronal correlates. Although several morphometric studies demonstrated that PD is associated with gray matter volume (GMV) reduction in olfactory and gustatory regions involved in disgust processing, a possible correlation with disgust proneness has not been investigated. We conducted a voxel-based morphometry analysis to compare GMV between 16 cognitively normal male PD patients with mild to moderate symptoms and 24 matched control subjects. All participants had answered questionnaires for the assessment of disgust proneness, trait anger and trait anxiety. We correlated questionnaire scores with GMV in both groups. The clinical group reported selectively reduced disgust proneness toward olfactory stimuli associated with spoilage. Moreover, they showed GMV reduction in the central olfactory system [orbitofrontal cortex (OFC) and piriform cortex]. Disgust items referring to olfactory processing were positively correlated with OFC volume in PD patients. Our data suggest an association between PD-associated neurodegeneration and olfactory related facets of the personality trait disgust proneness. (JINS, 2015, 21, 314–317)

Keywords

PersonalityAffective traitsOlfactory systemRevulsionStructural MRIVBM
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 21 , Issue 4 , April 2015 , pp. 314 - 317
Copyright
Copyright © The International Neuropsychological Society 2015 

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