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Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease

Published online by Cambridge University Press:  01 May 2004

ERIKA JONSSON LAUKKA ,
SARI JONES ,
BRENT J. SMALL ,
LAURA FRATIGLIONI  and
LARS BÄCKMAN
ERIKA JONSSON LAUKKA
Affiliation:
Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
SARI JONES
Affiliation:
Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
BRENT J. SMALL
Affiliation:
Department of Gerontology, University of South Florida, Tampa, Florida
LAURA FRATIGLIONI
Affiliation:
Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
LARS BÄCKMAN
Affiliation:
Aging Research Center, Division of Geriatric Epidemiology, Neurotec, Karolinska Institutet and Stockholm Gerontology Research Center, Stockholm, Sweden
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Abstract

We investigated whether (1) cognitive deficits are present among persons who will be diagnosed with vascular dementia (VaD) 3 years later, and (2) the pattern of such deficits is similar to that observed in preclinical Alzheimer's disease (AD). The VaD diagnosis was a diagnosis of post-stroke dementia. Population-based samples of 15 incident VaD cases, 43 incident AD cases, and 149 normal controls were compared on tests of episodic and short-term memory, verbal fluency, and visuospatial skill. Both dementia groups showed preclinical impairment relative controls on tasks assessing episodic memory 3 years before diagnosis, and there were no differences between these groups on any cognitive measure. The existence of a preclinical phase in the present VaD cases suggests that circulatory disturbance may affect cognitive performance before the occurrence of stroke that leads to clinical VaD. These results extend previous findings of similar patterns of cognitive deficits in the early clinical phases of AD and VaD to the preclinical phases of these diseases. (JINS, 2004, 10, 382–391.)

Keywords

Preclinical dementiaCognitionEpisodic memory
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 3 , May 2004 , pp. 382 - 391
Copyright
© 2004 The International Neuropsychological Society

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References

REFERENCES

Agüero-Torres, H., Winblad, B., & Fratiglioni, L. (1999). Epidemiology of vascular dementia: Some results despite research limitations. Alzheimer Disease and Associated Disorders, 13 (Suppl. 3), 15–20.Google Scholar
Almkvist, O., Bäckman, L., Basun, H., & Wahlund, L.-O. (1993). Patterns of neuropsychological performance in Alzheimer's disease and vascular dementia. Cortex, 29, 661–673.Google Scholar
Almkvist, O., Fratiglioni, L., Agüero-Torres, H., Viitanen, M., & Bäckman, L. (1999). Cognitive support at episodic encoding and retrieval: Similar patterns of utilization in community-based samples of Alzheimer's disease and vascular dementia patients. Journal of Clinical and Experimental Neuropsychology, 21, 816–830.Google Scholar
American Psychiatric Association. (1987). Diagnostic and Statistical Manual of Mental Disorders (3rd ed., rev.). Washington, DC: American Psychiatric Association Press.
American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC: American Psychiatric Association Press.
Bäckman, L. & Forsell, Y. (1994). Episodic memory functioning in a community-based sample of old adults with major depression: Utilization of cognitive support. Journal of Abnormal Psychology, 103, 361–370.Google Scholar
Bäckman, L., Small, B.J., & Wahlin, Å. (2001). Aging and memory: Cognitive and biological perspectives. In J.E. Birren & K.W. Schaie (Eds.), Handbook of the psychology of aging (5th ed., pp. 349–377). San Diego, California: Academic Press.
Bernick, C., Kuller, L., Dulberg, C., Longstreth, W.T., Manolio, T., Beauchamp, N., & Price, T. (2001). Silent MRI infarcts and the risk of future stroke: The cardiovascular health study. Neurology, 57, 1222–1229.CrossRefGoogle Scholar
Breteler, M.M.B., Claus, J.J., Grobbee, D.E., & Hofman, A. (1994a). Cardiovascular disease and distribution of cognitive function in elderly people: The Rotterdam study. British Medical Journal, 308, 1604–1608.Google Scholar
Breteler, M.M.B., van Amerongen, N.M., van Swieten, J.C., Claus, J.J., Grobbee, D.E., van Gijn, J., Hofman, A., & van Harskamp, F. (1994b). Cognitive correlates of ventricular enlargement and cerebral white matter lesions on magnetic resonance imaging: The Rotterdam study. Stroke, 25, 1109–1115.Google Scholar
Cabeza, R. & Nyberg, L. (2000). Imaging cognition II: An empirical review of 275 PET and fMRI studies. Journal of Cognitive Neuroscience, 12, 1–47.Google Scholar
Christensen, A.-L. (1984). Luria's neuropsychological investigation. Copenhagen, Denmark: Munksgaard.
Chui, H.C., Victoroff, J.I., Margolin, D., Jagust, W., Shankle, R., & Katzman, R. (1992). Criteria for the diagnosis of ischemic vascular dementia proposed by the State of California Alzheimer's Disease Diagnostic and Treatment Centers. Neurology, 42, 473–480.CrossRefGoogle Scholar
Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159.Google Scholar
Craik, F.I.M. & Jennings, J.M. (1992). Human memory. In F.I.M. Craik & T.A. Salthouse (Eds.), Handbook of aging and cognition (pp. 465–478). Hillsdale, New Jersey: Erlbaum.
de la Torre, J.C. (2002). Alzheimer disease as a vascular disorder: Nosological evidence. Stroke, 33, 1152–1162.Google Scholar
de Leeuw, F.-E., de Groot, J.C., & Breteler, M.M.B. (2000). White matter changes: Frequency and risk factors. In L. Pantoni, D. Inzitari, & A. Wallin (Eds). The matter of white matter: Clinical and pathophysiological aspects of white matter disease related to cognitive decline and vascular dementia (pp. 19–33). Utrecht, the Netherlands: Academic Pharmaceutical Productions.
Elias, M.F., Wolf, P.A., D'Agostino, R.B., Cobb, J., & White, L.R. (1993). Untreated blood pressure level is inversely related to cognitive functioning: The Framingham study. American Journal of Epidemiology, 138, 353–364.Google Scholar
Elias, M.F., Beiser, A., Wolf, P.A., Au, R., White, R.F., & D'Agostino, R.B. (2000). The preclinical phase of Alzheimer disease: A 22-year prospective study of the Framingham cohort. Archives of Neurology, 57, 808–813.Google Scholar
Erker, G.J., Searight, H.R., & Peterson, P. (1995). Patterns of neuropsychological functioning among patients with multi-infarct and Alzheimer's dementia: A comparative analysis. International Psychogeriatrics, 7, 393–406.Google Scholar
Erkinjuntti, T. (1999). Cerebrovascular dementia: Pathophysiology, diagnosis and treatment. CNS Drugs, 12, 35–48.Google Scholar
Erkinjuntti, T., Laaksonen, R., Sulkava, R., Syrjäläinen, R., & Palo, J. (1986). Neuropsychological differentiation between normal aging, Alzheimer's disease and vascular dementia. Acta Neurologica Scandinavia, 74, 393–403.Google Scholar
Fabrigoule, C., Lafont, S., Letenneur, L., Rouch, I., & Dartigues, J.-F. (1996). WAIS similarities subtest performances as predictors of dementia in elderly community residents. Brain and Cognition, 30, 323–326.Google Scholar
Fabrigoule, C., Rouch, I., Taberly, A., Letenneur, L., Commenges, D., Mazaux, J.-M., Orgogozo, J.-M., & Dartigues, J.-F. (1998). Cognitive process in preclinical phase of dementia. Brain, 121, 135–141.CrossRefGoogle Scholar
Fahlander, K., Wahlin, Å., Fastbom, J., Grut, M., Forsell, Y., Hill, R.D., Winblad, B., & Bäckman, L. (2000). The relationship between signs of cardiovascular deficiency and cognitive performance in old age: A population-based study. Journal of Gerontology: Psychological Sciences, 55B, 1–7.Google Scholar
Fahlander, K., Wahlin, Å., Almkvist, O., & Bäckman, L. (2002). Cognitive functioning in Alzheimer's disease and vascular dementia: Further evidence for similar patterns of deficits. Journal of Clinical and Experimental Neuropsychology, 24, 734–744.Google Scholar
Farkas, E. & Luiten, P.G.M. (2001). Cerebral microvascular pathology in aging and Alzheimer's disease. Progress in Neurobiology, 64, 575–611.CrossRefGoogle Scholar
Folstein, M.F., Folstein, S.E., & McHugh, P.R. (1975). “Mini-Mental State”: A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189–198.Google Scholar
Fratiglioni, L., Grut, M., Forsell, Y., Viitanen, M., Grafström, M., Holmén, K., Ericsson, K., Bäckman, L., Ahlbom, A., & Winblad, B. (1991). Prevalence of Alzheimer's disease and other dementias in an elderly urban population: Relationship with age, sex, and education. Neurology, 41, 1886–1892.CrossRefGoogle Scholar
Fratiglioni, L., Viitanen, M., Bäckman, L., Sandman, P.-O., & Winblad, B. (1992). Occurrence of dementia in advanced age: The study design of the Kungsholmen Project. Neuroepidemiology, 11, 29–36.CrossRefGoogle Scholar
Grober, E., Lipton, R.B., Hall, C., & Crystal, H. (2000). Memory impairment on free and cued selective reminding predicts dementia. Neurology, 54, 827–832.CrossRefGoogle Scholar
Hachinski, V.C. (1994). Vascular dementia: A radical redefinition. Dementia, 5, 130–132.Google Scholar
Hachinski, V.C., Iliff, L.D., Zilhka, E., Du Boulay, G.H., McAllister, V.L., Marshall, J., Russel, R.W.R., & Symon, L. (1975). Cerebral blood flow in dementia. Archives of Neurology, 32, 632–637.Google Scholar
Hachinski, V.C., Lassen, N.A., & Marshall, J. (1974). Multi-infarct dementia: A cause of mental deterioration in the elderly. Lancet, 2, 207–210.CrossRefGoogle Scholar
Hassing, L. & Bäckman, L. (1997). Episodic memory functioning in population-based samples of very old adults with Alzheimer's disease and vascular dementia. Dementia and Geriatric Cognitive Disorders, 8, 376–383.CrossRefGoogle Scholar
Howieson, D.B., Dame, A., Camicioli, R., Sexton, G., Payami, H., & Kaye, J.A. (1997). Cognitive markers preceding Alzheimer's dementia in the healthy oldest old. Journal of the American Geriatrics Society, 45, 584–589.Google Scholar
Jacobs, D.M., Sano, M., Dooneief, G., Marder, K., Bell, K.L., & Stern, Y. (1995). Neuropsychological detection and characterization of preclinical Alzheimer's disease. Neurology, 45, 957–962.Google Scholar
Kalaria, R.N. & Ballard, C. (1999). Overlap between pathology of Alzheimer disease and vascular dementia. Alzheimer Disease and Associated Disorders, 13 (Suppl. 3), 115–123.Google Scholar
Kramer, J.H., Reed, B.R., Mungas, D., Weiner, M.W., & Chui, H.C. (2002). Executive dysfunction in subcortical ischaemic vascular disease. Journal of Neurology, Neurosurgery and Psychiatry, 72, 217–220.CrossRefGoogle Scholar
Launer, L.J., Masaki, K., Petrovitch, H., Foley, D., & Havlik, R.J. (1995). The association between midlife blood pressure levels and late-life cognitive function: The Honolulu-Asia aging study. Journal of the American Medical Association, 274, 1846–1851.CrossRefGoogle Scholar
Lezak, M.D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.
Linn, R.T., Wolf, P.A., Bachman, D.L., Knoefel, J.E., Cobb, J.L., Belanger, A.J., Kaplan, E.F., & D'Agostino, R.B. (1995). The “preclinical phase” of probable Alzheimer's disease: A 13-year prospective study of the Framingham cohort. Archives of Neurology, 52, 485–490.CrossRefGoogle Scholar
Looi, J.C.L. & Sachdev, P.S. (1999). Differentiation of vascular dementia from AD on neuropsychological tests. Neurology, 53, 670–678.Google Scholar
Maeshima, S., Moriwaki, H., Ozaki, F., Okita, R., Yamaga, H., & Ueyoshi, A. (2002). Silent cerebral infarction and cognitive function in middle-aged neurologically healthy subjects. Acta Neurologica Scandinavia, 105, 179–184.Google Scholar
Marshall, R.S., Lazar, R.M., Pile-Spellman, J., Young, W.L., Duong, D.H., Joshi, S., & Ostapkovich, N. (2001). Recovery of brain function during induced cerebral hypoperfusion. Brain, 124, 1208–1217.CrossRefGoogle Scholar
McPherson, S.E. & Cummings, J.L. (1996). Neuropsychological aspects of vascular dementia. Brain and Cognition, 31, 269–282.CrossRefGoogle Scholar
Molander, B. (1984). Imagery, visual and tactual dimensions of imagery, and meaningfulness: Swedish norms for 854 nouns (Tech. Rep. No. 178). Umeå, Sweden: University of Umeå.
Moroney, J.T., Bagiella, E., Desmond, D.W., Hachinski, V.C., Mölsä, P.K., Gustafson, L., Brun, A., Fisher, P., Erkinjuntti, T., Rosen, W., Paik, M.C., & Tatemichi, T.K. (1997). Meta-analysis of the Hachinski Ischemic Score in pathologically verified dementias. Neurology, 49, 1096–1105.Google Scholar
Morris, J.C., Storandt, M., Miller, P., McKeel, D.W., Price, J.L., Rubin, E.H., & Berg, L. (2001). Mild cognitive impairment represents early-stage Alzheimer disease. Archives of Neurology, 58, 397–405.Google Scholar
Nyenhuis, D.L. & Gorelick, P.B. (1998). Vascular dementia: A contemporary review of epidemiology, diagnosis, prevention, and treatment. Journal of the American Geriatrics Society, 46, 1437–1448.Google Scholar
Qiu, C., Skoog, I., & Fratiglioni, L. (2002). Occurrence and determinants of vascular cognitive impairment. In T. Erkinjuntti & S. Gauthier (Eds.), Vascular cognitive impairment (pp. 61–83). London: Martin Dunitz.
Reed, B.R., Eberling, J.L., Mungas, D., Weiner, M.W., & Jagust, W.J. (2000). Memory failure has different mechanisms in subcortical stroke and Alzheimer's disease. Annals of Neurology, 48, 275–284.Google Scholar
Roman, G.C. & Royall, D.R. (1999). Executive control function: A rational basis for the diagnosis of vascular dementia. Alzheimer Disease and Associated Disorders, 13 (Suppl. 3), 69–80.CrossRefGoogle Scholar
Roman, G.C., Tatemichi, T.K., Erkinjuntti, T., Cummings, J.L., Masdeu, J.C., Garcia, J.H., Amaducci, L., Orgogozo, J.-M., Brun, A., Hofman, A., Moody, D.M., O'Brien, M.D., Yamaguchi, T., Grafman, J., Drayer, B.P., Bennett, D.A., Fisher, M., Ogata, J., Kokmen, E., Bermejo, F., Wolf, P.A., Gorelick, P.B., Bick, K.L., Pajeau, A.K., Bell, M.A., DeCarli, C., Culebras, A., Korczyn, A.D., Bogousslavsky, J., Hartmann, A., & Scheinberg, P. (1993). Vascular dementia: Diagnostic criteria for research studies: Report of the NINDS-AIREN International Workshop. Neurology, 43, 250–260.Google Scholar
Shi, J., Perry, G., Smith, M.A., & Friedland, R.P. (2000). Vascular abnormalities: The insidious pathogenesis of Alzheimer's disease. Neurobiology of Aging, 21, 357–361.CrossRefGoogle Scholar
Skoog, I. (1994). Risk factors for vascular dementia: A review. Dementia, 5, 137–144.Google Scholar
Skoog, I., Berg, S., Johansson, B., Palmertz, B., & Andreasson, L.A. (1996). The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurologica Scandinavia, 93, 142–148.Google Scholar
Small, B.J., Herlitz, A., Fratiglioni, L., Almkvist, O., & Bäckman, L. (1997). Cognitive predictors of incident Alzheimer's disease: A prospective longitudinal study. Neuropsychology, 11, 413–420.Google Scholar
Tierney, M.C., Szalai, J.P., Snow, W.G., Fisher, R.H., Nores, A., Nadon, G., Dunn, E., & St. George-Hyslop, P.H. (1996). Prediction of probable Alzheimer's disease in memory-impaired patients: A prospective longitudinal study. Neurology, 46, 661–665.CrossRefGoogle Scholar
Wechsler, D. (1981). Manual for the Wechsler Adult Intelligence Scale–Revised. New York: The Psychological Corporation.
Wong, T.Y., Klein, R., Sharrett, A.R., Couper, D.J., Klein, B.E.K., Liao, D.-P., Hubbard, L.D., & Mosley, T.H. (for the ARIC Investigators). (2002). Cerebral white matter lesions, retinopathy, and incident clinical stroke. Journal of the American Medical Association, 288, 67–74.CrossRefGoogle Scholar