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Structural MRI correlates of recognition memory in Alzheimer's disease

Published online by Cambridge University Press:  02 April 2001

Deborah A. Cahn ,
Edith V. Sullivan ,
Paula K. Shear ,
Laura Marsh ,
Rosemary Fama ,
Kelvin O. Lim ,
Jerome A. Yesavage ,
Jared R. Tinklenberg  and
and Adolf Pfefferbaum
Deborah A. Cahn
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
Edith V. Sullivan
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Paula K. Shear
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Laura Marsh
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
Rosemary Fama
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
Kelvin O. Lim
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
Jerome A. Yesavage
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
Jared R. Tinklenberg
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Psychiatry Service, VA Palo Alto Health Care System, Palo Alto, CA, USA
and Adolf Pfefferbaum
Affiliation:
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA Neuropsychiatry Program, SRI International, Menlo Park, CA, USA
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Abstract

Neuroimaging and lesion studies have demonstrated that hippocampal volume correlates with memory performance, but material-specific lateralization of this structure-function relationship has been inconsistent. This MRI study examined the relative contributions of left and right temporal lobe volumes to verbal and nonverbal recognition memory in a group of 20 Alzheimer's disease (AD) patients. There was a significant relationship between extent of right hippocampal and right temporal gray matter tissue volume deficit and performance on the face recognition subtest of the Warrington Recognition Memory Test. The face recognition test correlated with right hemisphere volume but not to left, indicating a material-specific relationship between brain structure and function in this patient group. Right temporal horn volume did not account for a significant proportion of variance in face recognition memory. Although word recognition was not significantly correlated with either left or right hippocampal volume in the total group, there was a strong correlation between left hippocampal volume and word recognition memory in the female AD patients. Thus, face recognition shows a material specific relationship with select lateralized hippocampal and temporal cortical volumes in AD patients, regardless of gender, whereas the verbal recognition–left-hippocampal volume relationship may be mediated by gender. (JINS, 1998, 4, 106–114.)

Keywords

MemoryAlzheimer's diseaseNeuroimaging
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 4 , Issue 2 , March 1998 , pp. 106 - 114
Copyright
© 1998 The International Neuropsychological Society

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Footnotes

Reprint requests to: Edith V. Sullivan, Department of Psychiatry & Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305-5717, USA.