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What it is said versus how it is said: Comprehension of affective prosody in men with Klinefelter (47,XXY) syndrome

Published online by Cambridge University Press:  18 October 2007

SOPHIE VAN RIJN ,
ANDRÉ ALEMAN ,
HANNA SWAAB ,
TESSEL KRIJN ,
GUY VINGERHOETS  and
RENÉ S. KAHN
SOPHIE VAN RIJN
Affiliation:
Helmholtz Instituut, Department of Experimental Psychology, Universiteit Utrecht, Utrecht, The Netherlands Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Department of Clinical Child and Adolescent Studies, Leiden University, Leiden, The Netherlands
ANDRÉ ALEMAN
Affiliation:
BCN NeuroImaging Center, University of Groningen, Groningen, The Netherlands
HANNA SWAAB
Affiliation:
Department of Clinical Child and Adolescent Studies, Leiden University, Leiden, The Netherlands
TESSEL KRIJN
Affiliation:
Helmholtz Instituut, Department of Experimental Psychology, Universiteit Utrecht, Utrecht, The Netherlands
GUY VINGERHOETS
Affiliation:
Laboratory for Neuropsychology, Ghent University, Ghent, Belgium
RENÉ S. KAHN
Affiliation:
Department of Psychiatry, Rudolf Magnus Institute for Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
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Abstract

Difficulties in social communication in individuals with Klinefelter syndrome (XXY chromosomal pattern) have largely been attributed to deficits in left hemisphere-mediated, language functions. This study examined the ability of XXY men to decode emotions from tone of voice, a pragmatic aspect of social communication that may be associated with right hemisphere functioning. A total of 26 XXY men and 20 men from the general population completed tasks involving emotion discrimination in speech, based on verbal content or tone of voice. The XXY group displayed relative difficulties in discriminating emotions in tone of voice, and, to a lesser extend, in verbal content. This finding suggests that the XXY chromosomal pattern may not only be associated with difficulties in semantic aspects of language, but with prosodic aspects, as well. Our findings may contribute to the development of more comprehensive models addressing the role of the X chromosome in normal and abnormal development of social communication. (JINS, 2007, 13, 1065–1070.)

Keywords

Nonverbal communicationEmotionsSocial behaviorAuditory perceptionSex chromosome disordersX chromosome
Type
BRIEF COMMUNICATION
Information
Journal of the International Neuropsychological Society , Volume 13 , Issue 6 , November 2007 , pp. 1065 - 1070
Copyright
© 2007 The International Neuropsychological Society

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References

REFERENCES

Bender, B.G., Harmon, R.J., Linden, M.G., Bucher-Bartelson, B., & Robinson, A. (1999). Psychosocial competence of unselected young adults with sex chromosome abnormalities. American Journal of Medical Genetics—Neuropsychiatric Genetics, 88, 200.3.0.CO;2-3>CrossRefGoogle Scholar
Boone, K.B., Swerdloff, R.S., Miller, B.L., Geschwind, D.H., Razani, J., Lee, A., Gonzalo, I.G., Haddal, A., Rankin, K., Lu, P., & Paul, L. (2001). Neuropsychological profiles of adults with Klinefelter syndrome. Journal of the International Neuropsychological Society, 7, 446–456.CrossRefGoogle Scholar
Geschwind, D.H., Boone, K.B., Miller, B.L., & Swerdloff, R.S. (2000). Neurobehavioral phenotype of Klinefelter syndrome. Mental Retardation and Developmental Disabilities Research Reviews, 6, 107–116.3.0.CO;2-2>CrossRefGoogle Scholar
Itti, E., Gaw Gonzalo, I.T., Boone, K.B., Geschwind, D.H., Berman, N., Pawlikowska-Haddal, A., Itti, L., Mishkin, F.S., & Swerdloff, R.S. (2003). Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome. Annals of Neurology, 54, 669–673.CrossRefGoogle Scholar
Itti, E., Gaw Gonzalo, I.T., Pawlikowska-Haddal, A., Boone, K.B., Mlikotic, A., Itti, L., Mishkin, F.S., & Swerdloff, R.S. (2006). The structural brain correlates of cognitive deficits in adults with Klinefelter's syndrome. Journal of Clinical Endocrinology and Metabolism, 91, 1423–1427.CrossRefGoogle Scholar
Joanette, Y., Goulet, P., & Hannequin, D. (1990). Right hemisphere and verbal communication. New York: Springer-Verlag.CrossRef
Lezak, M.D. (1995). Neuropsychological assessment (3rd ed.). New York: Oxford University Press.
Mitchell, R.L., Elliott, R., Barry, M., Cruttenden, A., & Woodruff, P.W. (2003). The neural response to emotional prosody, as revealed by functional magnetic resonance imaging. Neuropsychologia, 41, 1410–1421.CrossRefGoogle Scholar
Nelson, H.E. (1982). National Adult Reading Test (NART), manual. Windsor, Bershire, UK: NFER-Nelson.
Oldfield, R.C. (1971). The assessment and analysis of handedness: The Edinburgh inventory. Neuropsychologia, 9, 97–113.CrossRefGoogle Scholar
Ratcliffe, S. (1999). Long-term outcome in children of sex chromosome abnormalities. Archives of Disease in Childhood, 80, 192–195.CrossRefGoogle Scholar
Ross, E.D., Thompson, R.D., & Yenkosky, J. (1997). Lateralization of affective prosody in brain and the callosal integration of hemispheric language functions. Brain and Language, 56, 27–54.CrossRefGoogle Scholar
Ross, J.L., Stefanatos, G., Roeltgen, D., Kushner, H., & Cutler, G.B., Jr. (1995). Ullrich-Turner syndrome: Neurodevelopmental changes from childhood through adolescence. American Journal of Medical Genetics, 58, 74.CrossRefGoogle Scholar
Rovet, J., Netley, C., Keenan, M., Bailey, J., & Stewart, D. (1996). The psychoeducational profile of boys with Klinefelter syndrome. Journal of Learning Disabilities, 29, 193–196.CrossRefGoogle Scholar
Schmand, B., Bakker, D., Saan, R., & Louman, J. (1991). [The Dutch Reading Test for Adults: A measure of premorbid intelligence level]. Tijdschrift voor Gerontologie en Geriatrie, 22, 15–19.Google Scholar
Sheehan, D.V., Lecrubier, Y., Sheehan, K.H., Amorim, P., Janavs, J., Weiller, E., Hergueta, T., Baker, R., & Dunbar, G.C. (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. Journal of Clinical Psychiatry, 59(Suppl. 20), 22–33; quiz 34–57.Google Scholar
Shepard, R.N. & Metzler, J. (1971). Mental rotation of three-dimensional objects. Science, 171, 701–703.CrossRefGoogle Scholar
Van Rijn, S., Aleman, A., Swaab, H., Vink, M., Sommer, I., & Kahn, R.S. (submitted). Effects of an extra X chromosome on language lateralization: An fMRI study with Klinefelter (XXY) men.
Van Rijn, S., Aleman, A., van Diessen, E., Berckmoes, C., Vingerhoets, G., & Kahn, R.S. (2005). What is said or how it is said makes a difference: Role of the right fronto-parietal operculum in emotional prosody as revealed by repetitive TMS. European Journal of Neuroscience, 21, 3195–3200.CrossRefGoogle Scholar
Van Rijn, S., Swaab, H., Aleman, A., & Kahn, R.S. (2006). X chromosomal effects on social cognitive processing and emotion regulation: A study with Klinefelter men (47,XXY). Schizophrenia Research, 84, 194–203.CrossRefGoogle Scholar
Vingerhoets, G., Berckmoes, C., & Stroobant, N. (2003). Cerebral hemodynamics during discrimination of prosodic and semantic emotion in speech studied by transcranial doppler ultrasonography. Neuropsychology, 17, 93–99.CrossRefGoogle Scholar
Vingerhoets, G. & Luppens, E. (2001). Cerebral blood flow velocity changes during dichotic listening with directed or divided attention: A transcranial doppler ultrasonography study. Neuropsychologia, 39, 1105.CrossRefGoogle Scholar
Willshire, D., Kinsella, G., & Prior, M. (1991). Estimating WAIS-R IQ from the National Adult Reading Test—a cross-validation. Journal of Clinical and Experimental Neuropsychology, 13, 204–216.CrossRefGoogle Scholar