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Working memory deficits in multiple sclerosis: Comparison between the n-back task and the Paced Auditory Serial Addition Test

Published online by Cambridge University Press:  08 September 2006

BRETT A. PARMENTER ,
JANET L. SHUCARD ,
RALPH H.B. BENEDICT  and
DAVID W. SHUCARD
BRETT A. PARMENTER
Affiliation:
Division of Developmental and Behavioral Neurosciences, Department of Neurology/The Jacobs Neurological Institute, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York
JANET L. SHUCARD
Affiliation:
Division of Developmental and Behavioral Neurosciences, Department of Neurology/The Jacobs Neurological Institute, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York
RALPH H.B. BENEDICT
Affiliation:
Division of Developmental and Behavioral Neurosciences, Department of Neurology/The Jacobs Neurological Institute, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York
DAVID W. SHUCARD
Affiliation:
Division of Developmental and Behavioral Neurosciences, Department of Neurology/The Jacobs Neurological Institute, University at Buffalo, State University of New York, School of Medicine and Biomedical Sciences, Buffalo, New York
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Abstract

Working memory (WM) deficits are common in multiple sclerosis (MS). The Paced Auditory Serial Addition Test (PASAT) is used frequently to measure WM in clinical settings. The n-back paradigm is used often in experimental studies of WM. One unique component of the n-back task is that it provides a measure of reaction time (RT), an additional behavioral index of processing speed and task difficulty. Despite the use of both tasks to measure WM, their common variance has not been documented. We tested 32 MS patients and 20 controls; performance measures were obtained for both tasks. Compared with controls, MS patients generally had poorer performance on both the PASAT and n-back task. MS patients also had slower RTs on the n-back than controls and showed more slowing than controls as a function of WM load. Correlational analyses showed a high correspondence between performance measures on the PASAT and n-back. Principal components analysis pointed to a common feature of the PASAT, n-back, and specific other neuropsychological measures, that is, processing speed. Although the PASAT and n-back were shown to have a significant amount of shared variance, each test has specific advantages and disadvantages for use in clinical populations (JINS, 2006, 12, 677–687.)

Keywords

Autoimmune diseaseInformation processing speedAttentionCognitive impairmentTrail making testHuman
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 5 , September 2006 , pp. 677 - 687
Copyright
© 2006 The International Neuropsychological Society

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