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Worth the Wait: Delayed Recall after 1 Week Predicts Cognitive and Medial Temporal Lobe Trajectories in Older Adults

Published online by Cambridge University Press:  14 October 2020

Cutter A. Lindbergh Open the ORCID record for Cutter A. Lindbergh [Opens in a new window] ,
Nicole Walker ,
Renaud La Joie Open the ORCID record for Renaud La Joie [Opens in a new window] ,
Sophia Weiner-Light ,
Adam M. Staffaroni ,
Kaitlin B. Casaletto ,
Fanny Elahi ,
Samantha M. Walters ,
Michelle You  and
Devyn Cotter
...Show all authors
Cutter A. Lindbergh*
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Nicole Walker
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Renaud La Joie
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Sophia Weiner-Light
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Adam M. Staffaroni
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Kaitlin B. Casaletto
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Fanny Elahi
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Samantha M. Walters
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Michelle You
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Devyn Cotter
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Breton Asken
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Alexandra C. Apple
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Elena Tsoy
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
John Neuhaus
Affiliation:
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA
Corrina Fonseca
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Amy Wolf
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Yann Cobigo
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Howie Rosen
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
Joel H. Kramer
Affiliation:
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA
*
*Correspondence and reprint requests to: Dr. Cutter A. Lindbergh, Memory and Aging Center, Department of Neurology, University of California San Francisco, 675 Nelson Rising Lane, Suite 190, San Francisco, CA94143, USA. E-mail: Cutter.Lindbergh@ucsf.edu
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Abstract

Objective: We evaluated whether memory recall following an extended (1 week) delay predicts cognitive and brain structural trajectories in older adults
Method:

Clinically normal older adults (52–92 years old) were followed longitudinally for up to 8 years after completing a memory paradigm at baseline [Story Recall Test (SRT)] that assessed delayed recall at 30 min and 1 week. Subsets of the cohort underwent neuroimaging (N = 134, mean age = 75) and neuropsychological testing (N = 178–207, mean ages = 74–76) at annual study visits occurring approximately 15–18 months apart. Mixed-effects regression models evaluated if baseline SRT performance predicted longitudinal changes in gray matter volumes and cognitive composite scores, controlling for demographics.

Results:

Worse SRT 1-week recall was associated with more precipitous rates of longitudinal decline in medial temporal lobe volumes (p = .037), episodic memory (p = .003), and executive functioning (p = .011), but not occipital lobe or total gray matter volumes (demonstrating neuroanatomical specificity; p > .58). By contrast, SRT 30-min recall was only associated with longitudinal decline in executive functioning (p = .044).

Conclusions:

Memory paradigms that capture longer-term recall may be particularly sensitive to age-related medial temporal lobe changes and neurodegenerative disease trajectories. (JINS, 2020, xx, xx-xx)

Keywords

Alzheimer’s diseaseCognitive agingEarly diagnosisEpisodic memoryLearningTemporal lobe
Type
Brief Communication
Information
Journal of the International Neuropsychological Society , Volume 27 , Issue 4 , April 2021 , pp. 382 - 388
Copyright
Copyright © INS. Published by Cambridge University Press, 2020

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