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The Role of Cell-Cell Adhesion in the Formation of Multicellular Sprouts

Published online by Cambridge University Press:  03 February 2010

A. Szabó  and
A. Czirók
A. Szabó
Affiliation:
Department of Biological Physics, Eötvos University, Budapest, Hungary
A. Czirók*
Affiliation:
Department of Biological Physics, Eötvos University, Budapest, Hungary Department of Anatomy & Cell Biology, University of Kansas Medical Center Kansas City, KS, USA
*
*Corresponding author: aczirok@kumc.edu
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Abstract

Collective cell motility and its guidance via cell-cell contacts is instrumental in several morphogenetic and pathological processes such as vasculogenesis or tumor growth. Multicellular sprout elongation, one of the simplest cases of collective motility, depends on a continuous supply of cells streaming along the sprout towards its tip. The phenomenon is often explained as leader cells pulling the rest of the sprout forward via cell-cell adhesion. Building on an empirically demonstrated analogy between surface tension and cell-cell adhesion, we demonstrate that such a mechanism is unable to recruit cells to the sprout. Moreover, the expansion of such hypothetical sprouts is limited by a form of the Plateau-Taylor instability. In contrast, actively moving cells – guided by cell-cell contacts – can readily populate and expand linear sprouts. We argue that preferential attraction to the surfaces of elongated cells can provide a generic mechanism, shared by several cell types, for multicellular sprout formation.

Keywords

sproutingleader cellPotts model
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 5 , Issue 1: Cell migration , 2010 , pp. 106 - 122
Copyright
© EDP Sciences, 2010

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