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Stippling the Skin: Generation of Anatomical Periodicityby Reaction-Diffusion Mechanisms

Published online by Cambridge University Press:  11 July 2009

D. J. Headon  and
K. J. Painter
D. J. Headon*
Affiliation:
The Roslin Institute and Royal (Dick) School of Veterinary Studies University of Edinburgh, Midlothian, EH25 9PS, UK
K. J. Painter
Affiliation:
Department of Mathematics and Maxwell Institute for Mathematical Sciences, School of Mathematical and Computer Sciences, Heriot-Watt University, Edinburgh, EH14 4AS, UK
*
denis.headon@roslin.ed.ac.uk K.J.Painter@ma.hw.ac.uk
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Abstract

During vertebrate development cells acquire different fates depending largely ontheir location in the embryo. The definition of a cell's developmentalfate relies on extensive intercellular communication that produces positionalinformation and ultimately generates an appropriately proportioned anatomy. Herewe place reaction-diffusion mechanisms in the context of general conceptsregarding the generation of positional information during development and thenfocus on these mechanisms as parsimonious systems for positioning anatomicalstructures relative to one another. In particular, we discuss the evidence forreaction-diffusion systems operating in the developing skin to yield theperiodic arrangements of hairs and feathers and discuss how best tobring together experimental molecular biology and numerical simulations to yielda more complete understanding of the mechanisms of development and naturalvariation.

Keywords

reaction-diffusionpattern formationfeatherhairplacode
Type
Research Article
Information
Mathematical Modelling of Natural Phenomena , Volume 4 , Issue 4: Morphogenesis , 2009 , pp. 83 - 102
Copyright
© EDP Sciences, 2009

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