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Advances Toward Forming Synthetic Mimetic Tendon

Published online by Cambridge University Press:  11 April 2016

Dilinazi Aishanjiang ,
Emily C. Green ,
Heng Li  and
Marilyn L. Minus
Dilinazi Aishanjiang*
Affiliation:
Mechanical and Industrial Engineering Department, Northeastern University, Boston, MA 02115, U.S.A
Emily C. Green
Affiliation:
Mechanical and Industrial Engineering Department, Northeastern University, Boston, MA 02115, U.S.A
Heng Li
Affiliation:
Mechanical and Industrial Engineering Department, Northeastern University, Boston, MA 02115, U.S.A
Marilyn L. Minus
Affiliation:
Mechanical and Industrial Engineering Department, Northeastern University, Boston, MA 02115, U.S.A
*
*(Email: aishanjiang.d@husky.neu.edu)
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Abstract

Collagen is the most abundant protein present in the human body and found in connective tissues, bone, and tendon. It is also known as a natural resource for healing damaged skin tissues [1]. In this study, under specific microenvironment conditions, mimetic collagen gels were successfully formed synthetically from reconstituted Bovine type I collagen monomers. This was achieved by controlling ionic strength, temperature and pH, allowing fibrils with native mimetic D periodic banding structure to assemble spontaneously within the gels. In addition, by providing appropriate aging temperatures and times, mature collagen fibril growth is also realized in the gels in vitro. Mimetic gels were subsequently formed into fibers through a wet-spinning process. These spun fibers were found to preserve the native mimetic D periodic banding and fibrillar structure formed in the initial gels. As a result, the synthetic fibers resemble native tendon. Here structural development within the gel samples and fibers as a function of processing was analyzed by scanning electron microscopy (SEM). Results in this study also show a potentially new route for the fabrication of synthetic collagen fibers mimicking tendon, which may find applications as engineered tissues or scaffolding materials.

Keywords

biomimetic (assembly)biomaterialfiber
Type
Articles
Information
MRS Advances , Volume 1 , Issue 18: Biomaterials and Soft Materials , 2016 , pp. 1283 - 1288
Copyright
Copyright © Materials Research Society 2016 

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