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Development of a Flexible MIP-Based Biosensor Platform for the Thermal Detection of Neurotransmitters

Published online by Cambridge University Press:  05 January 2018

Kai Betlem ,
Michael P. Down ,
Christopher W. Foster ,
Shamima Akthar ,
K. Eersels ,
B. van Grinsven ,
T.J. Cleij ,
C.E. Banks  and
M. Peeters
Kai Betlem
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Michael P. Down
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Christopher W. Foster
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
Shamima Akthar
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
K. Eersels
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
B. van Grinsven
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
T.J. Cleij
Affiliation:
Maastricht University, Maastricht Science Programme, P.O. Box 616, 6200MD Maastricht, The Netherlands.
C.E. Banks
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
M. Peeters*
Affiliation:
Manchester Metropolitan University, Faculty of Science and Engineering, Div. of Chemistry & Environmental Science, John Dalton Building, Chester Street, M15GD, Manchester, United Kingdom.
*
*(Email: m.peeters@mmu.ac.uk)
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Abstract

We have developed high affinity Molecularly Imprinted Polymers (MIPs) for neurotransmitters such as dopamine, noradrenaline and caffeine. These polymer particles are mixed within the bulk of screen-printed ink allowing masss-producible bulk modified MIP Screen-Printed Electrodes (MIP-SPEs) to be realised. We have explored different SPE supporting surfaces, such as polyester, tracing paper and household-printing paper. The performance of those MIP-SPEs is studied using the Heat-Transfer Method (HTM), a patented thermal method. With the combination of screen-printing techniques and thermal detection, it is possible to develop a portable sensor platform that is capable of low-cost and straightforward detection of biomolecules on-site. In the future, this unique sensor architecture holds great promise for the use in biomedical devices.

Keywords

sensorpolymerbiomimetic (chemical reaction)
Type
Articles
Information
MRS Advances , Volume 3 , Issue 28: Biomaterials and Soft Materials , 2018 , pp. 1569 - 1574
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Copyright
Copyright © Materials Research Society 2017 

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References

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