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Oxygen Monitor to Study Vascularization of Medical Devices

Published online by Cambridge University Press:  03 February 2020

Avid Najdahmadi Open the ORCID record for Avid Najdahmadi [Opens in a new window] ,
Rachel Gurlin Open the ORCID record for Rachel Gurlin [Opens in a new window] ,
Mellonie Zhang ,
Jonathan RT Lakey  and
Elliot Botvinick
Avid Najdahmadi
Affiliation:
Department of Materials Science and Engineering, University of California Irvine, Irvine, USA
Rachel Gurlin
Affiliation:
Department of Biomedical Engineering, University of California Irvine, Irvine, USA
Mellonie Zhang
Affiliation:
Department of Biomedical Engineering, University of California Irvine, Irvine, USA
Jonathan RT Lakey
Affiliation:
Department of Biomedical Engineering, University of California Irvine, Irvine, USA Department of Surgery, University of California Irvine, Irvine, USA
Elliot Botvinick*
Affiliation:
Department of Materials Science and Engineering, University of California Irvine, Irvine, USA Department of Biomedical Engineering, University of California Irvine, Irvine, USA Department of Surgery, University of California Irvine, Irvine, USA
*
†(Email: elliot.botvinick@uci.edu)

Abstract:

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Prevascularized medical devices can improve cell therapy. Such devices may replace whole organ transplantation with hosting only the necessary therapeutic cells. We have developed a noninvasive optical technology to study the vascularization into such medical devices. In our technique, oxygen partial pressure within a device is monitored by Oxygen Sensitive Tubes (OSTs), comprising oxygen permeable silicone tubing with inner luminal surfaces coated by an oxygen-sensitive porphyrin dye. OSTs were placed within a PDMS device and transplanted into the subcutaneous space of athymic nude mice. An optical probe placed over the skin excites the OSTs with a pulse of light and detects the luminescent lifetime of emitted light, which is uniquely related to oxygen partial pressure. Furthermore, we developed a Dynamic Inhalation Gas Test (DIGT) to determine the oxygen transport rate between the microvasculature and the device. DIGT works by monitoring oxygen partial pressure in a device following a step change in inhaled-gas oxygen content. We report DIGT oxygen dynamics measured intermittently over eight weeks. Our study shows DIGT dynamics are unique to each implant, supporting the important role of the host tissue response in the availability of oxygen over time.

Keywords

biomaterialbiomedicalcellular (material form)optical propertiestissue
Type
Articles
Information
MRS Advances , Volume 5 , Issue 18-19: Soft Materials and Biomaterials , 2020 , pp. 991 - 1000
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Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
Copyright © The Author(s), 2020, published on behalf of Materials Research Society by Cambridge University Press

Footnotes

*

These authors contributed equally

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