Hostname: page-component-78c5997874-g7gxr Total loading time: 0 Render date: 2024-11-11T03:30:04.717Z Has data issue: false hasContentIssue false
  • English
  • Français

Towards the Development of a Cartilage-like Nanofiber-Hydrogel Composite

Published online by Cambridge University Press:  13 April 2020

Jacob M. Ludwick  and
Michelle L. Oyen
Jacob M. Ludwick
Affiliation:
Department of Engineering, East Carolina University, E 5th St. Greenville, NC 27858, U.S.A
Michelle L. Oyen*
Affiliation:
Department of Engineering, East Carolina University, E 5th St. Greenville, NC 27858, U.S.A
*
*(Email: oyenm18@ecu.edu)
Get access

Abstract

Articular cartilage plays an important role in synovial joint function, but this function is diminished when cartilage tissue breaks down in osteoarthritis. Tissue engineering is a promising approach for replacing failed cartilage, as cartilage is a relatively simple tissue with no blood supply and very few biological cells. To imitate the structure of natural cartilage extracellular matrix material, three components must be included: the hydrated ground substance, the charges that contribute to compressive stiffness via electrostatic repulsion, and the nanofibrous collagen network that resists tensile deformation and failure. Here, the nanofiber network is considered, with examination of its fracture behavior in an as-electrospun state and following a mild chemical crosslinking process. Mode III fracture testing was used to quantify the tear toughness of the fibrous mats, and failure behavior was qualitatively examined with scanning electron microscopy. In ongoing work, this nanofibrous structure will be combined with a charged polyelectrolyte hydrogel gel to create a biomimetic cartilage-like material. By using biomimicry to replicate what is present in native cartilage tissue, a superior material can be designed and fabricated for use in tissue repair and replacement.

Keywords

biomimeticfracturenanostructure
Type
Articles
Information
MRS Advances , Volume 5 , Issue 33-34: Mechanical Behavior and Structural Materials , 2020 , pp. 1783 - 1790
Check for updates
Copyright
Copyright © Materials Research Society 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Murphy, L. B., Cisternas, M. G., Pasta, D. J., Helmick, C. G., and Yelin, E. H., Arthritis Care Res., 70, 869–876 (2018).CrossRefGoogle Scholar
Martin, J. R., Watts, C. D., Levy, D. L., and Kim, R. H., J. Arthroplasty, 32, 558–562 (2017).CrossRefGoogle Scholar
Van Lenthe, G. H., De Waal Malefijt, M. C., and Huiskes, R., J. Bone Jt. Surg. B, 79, 117–122 (1997).CrossRefGoogle Scholar
Harris, J. D., Siston, R. A., Pan, X., and Flanigan, D. C., J. Bone Jt. Surg. A, 92, 2220–2233 (2010).CrossRefGoogle Scholar
Mithoefer, K., Mcadams, T., Williams, R. J., Kreuz, P. C., and Mandelbaum, B. R., Am. J. Sports Med., 37, 2053–2063 (2009).CrossRefGoogle Scholar
Mow, V. C., Gu, W. Y., and Chen, F. H., in Basic Orthopaedic Biomechanics and Mechano-Biology, 3rd ed., edited by Mow, V. C., and Huiskes, R., (Philadelphia: Lippincott Williams & Wilkins, 2005).Google Scholar
Shapiro, J. M. and Oyen, M. L., “Hydrogel composite materials for tissue engineering scaffolds,” JOM, 65, 505–516 (2013).CrossRefGoogle Scholar
Anjum, F., Carroll, A., Young, S. A., Flynn, L. E., and Amsden, B. G., Macromolecular Biosci. 17, 1600373 (2017).CrossRefGoogle Scholar
Caló, E. and V Khutoryanskiy, V., Eur. Polymer J. 65, 252–267 (2015).CrossRefGoogle Scholar
Wang, J., Zhang, F., Pui, W., Wan, C., and Wu, C., Biomaterials, 120, 11–21 (2017).CrossRefGoogle Scholar
Strange, D. G. T., Tonsomboon, K., and Oyen, M. L., J. Mater. Sci. Mater. Med., 25, 681–690 (2014).CrossRefGoogle Scholar
Tonsomboon, K., Butcher, A. L., and Oyen, M. L., Mater. Sci. Eng. C, 72, 220–227 (2017).CrossRefGoogle Scholar
Jiang, Q., Xu, H., Cai, S., and Yang, Y., J. Mater. Sci. Mater. Med. 25, 1789–1800 (2014).CrossRefGoogle Scholar
Tonsomboon, K., Koh, C.T., and Oyen, M. L., J. Mech. Behav. Biomed. Mater. 34, 116–123 (2014).CrossRefGoogle Scholar
Offeddu, G. S., Mela, I., Jeggle, P., Henderson, R. M., Smoukov, S. K., and Oyen, M. L., Sci. Rep., 7, 42948 (2017).CrossRefGoogle Scholar