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Peptide-Enhanced Nucleic Acid Delivery

Published online by Cambridge University Press:  31 January 2011

Jamie M. Bergen  and
Suzie H. Pun
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Abstract

Numerous barriers, both extracellular and intracellular, hinder successful and efficient nonviral nucleic acid delivery. Due to their small size and ability to specifically recognize and interact with molecular targets, peptides can be incorporated as modular elements into synthetic nucleic acid delivery systems to overcome many of these barriers. Three classes of peptides that have frequently been integrated as components in nucleic acid delivery systems include cell-penetrating peptides (CPPs), endosomal release peptides, and nuclear localization sequences (NLSs).Various additional classes of peptides show promise for enhancing nucleic acid delivery by targeting cell surface receptors, inhibiting nuclease activity, and directing nucleic acids toward intracellular targets. In addition to a review of the various existing approaches to peptide-enhanced nucleic acid delivery, this article will discuss strategies for the development of new peptides and approaches for the incorporation of these peptides into nucleic acid delivery systems.

Keywords

biomedical materialsnucleic acid deliverypeptides.
Type
Research Article
Information
MRS Bulletin , Volume 30 , Issue 9: Designer Materials for Nucleic Acid Delivery , September 2005 , pp. 663 - 667
Copyright
Copyright © Materials Research Society 2005

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