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Novel methods for in situ characterization of individual micro- and nanoscale magnetic particles

Published online by Cambridge University Press:  13 November 2013

John Moreland ,
Yoshihiro Nakashima ,
Jacob W. Alldredge  and
Gary Zabow
John Moreland
Affiliation:
National Institute of Standards and Technology, Boulder, CO; moreland@boulder.nist.gov
Yoshihiro Nakashima
Affiliation:
National Institute of Standards and Technology, Boulder, CO; yoshihiro.nakashima@nist.gov
Jacob W. Alldredge
Affiliation:
National Institute of Standards and Technology, Boulder, CO; alldredg@boulder.nist.gov
Gary Zabow
Affiliation:
National Institute of Neurological Disorders and Stroke, Bethesda, MD; zabowg@mail.nih.gov
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Abstract

New instrumentation is being developed to better understand the in vivo properties of magnetic particles suspended in solution or lodged in tissue. We describe three novel methods with the necessary sensitivity to measure the microscopic magnetic properties of individual magnetic particles and complexes quantitatively. The first method is based on proton nuclear magnetic resonance of a magnetic particle suspended in water in a microcapillary probe; the second method uses high-resolution magnetic resonance imaging of water surrounding a magnetic particle; and the third method is based on AC susceptometry with a magnetic cantilever that combines magnetic particle imaging concepts with probe microscopy. We present the physical basis for the measurements, estimate sensitivity limits, and discuss future impacts on the development of magnetic particles for bioimaging and bioassays.

Keywords

Biomedicalcolloidmagnetic propertiesnuclear magnetic resonancescanning probe microscopy
Type
Magnetic Nanoparticles
Information
MRS Bulletin , Volume 38 , Issue 11: Magnetic Nanoparticles , November 2013 , pp. 933 - 937
Copyright
Copyright © Materials Research Society 2013 

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