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Shifting identities of metal oxide nanoparticles: Focus on inflammation

Published online by Cambridge University Press:  13 November 2014

Kunal Bhattacharya ,
Lucian Farcal  and
Bengt Fadeel
Kunal Bhattacharya
Affiliation:
Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Sweden; kunal.bhattacharya@ki.se
Lucian Farcal
Affiliation:
Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Sweden; lucian.farcal@ki.se
Bengt Fadeel
Affiliation:
Nanosafety and Nanomedicine Laboratory, Institute of Environmental Medicine, Karolinska Institutet, Sweden; bengt.fadeel@ki.se
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Abstract

Metal and metal oxide nanoparticles are an important class of materials with numerous applications. Understanding how such nanoparticles interact with living systems is of considerable relevance both from a toxicological and biomedical perspective. The physicochemical features of nanoparticles are sometimes referred to as the synthetic identity, while the acquired properties of nanoparticles in a biological milieu resulting from the adsorption of biomolecules on the surface of the particles can be considered the biological identity. In this article, we explore the dynamic changes in the identity of nanoparticles resulting either from acquisition of a so-called bio-corona or through the process of biotransformation and how this impacts cellular recognition of nanoparticles and toxicological outcomes, with an emphasis on inflammation—an orchestrated host response against harmful stimuli, including pathogens as well as particles.

Keywords

Metalmetal oxidenanomaterialpropertiestransformationsustainability
Type
Research Article
Information
MRS Bulletin , Volume 39 , Issue 11: Biological Interactions of Oxide Nanoparticles: The Good and The Evil , November 2014 , pp. 970 - 975
Copyright
Copyright © Materials Research Society 2014 

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