Hostname: page-component-6bf8c574d5-2jptb Total loading time: 0 Render date: 2025-02-22T08:08:17.731Z Has data issue: false hasContentIssue false
  • English
  • Français

Aqueous Processing of L-Glutathione Capped ZnO Quantum dots for Potential Biomedical Applications

Published online by Cambridge University Press:  18 May 2015

Raquel Feliciano-Crespo ,
José A Rodriguez ,
Myrna Reyes-Blas ,
Chuan-Jian Zhong  and
Oscar Perales-Perez
Raquel Feliciano-Crespo
Affiliation:
Department of Chemistry, University of Puerto Rico, Mayaguez, PR, USA.
José A Rodriguez
Affiliation:
Department of Engineering Science & Materials, University of Puerto Rico, Mayaguez, PR, USA.
Myrna Reyes-Blas
Affiliation:
Department of Chemistry, University of Puerto Rico, Mayaguez, PR, USA.
Chuan-Jian Zhong
Affiliation:
Department of Chemistry, State University of New York, Binghamton, NY, USA.
Oscar Perales-Perez
Affiliation:
Department of Engineering Science & Materials, University of Puerto Rico, Mayaguez, PR, USA.
Get access

Abstract

Medical research has demonstrated the importance of the utilization of stable, fluorescent nanoprobes. The present work addresses the applicability of biocompatible and fluorescent ZnO nanoparticles as probes for detection of pathogens with the aim of achieving extremely low detection limits. For this purpose, ZnO surface must be functionalized for its subsequent interaction with bacterial cellular membrane (coupling), which will allow the corresponding detection and quantification. Herein we will discuss the aqueous synthesis of stable, water soluble and biologically compatible ZnO nanoparticles (NPss) capped with L-glutathione (GSH). The understanding of the interactions between GSH molecules and surface atoms in ZnO QDs became critical to foster the applicability of this nanomaterial in the biomedical and bioengineering fields. In this regard, the GSH/ZnO molar ratios, reaction temperature (40°C and 60°C), time and pH (6-9) became crucial factors to attain suitable tuning of the QDs properties. ZnO/GSH synthesized QDs were characterized by Transmission Electron Microscopy, X-Ray Diffraction, FT-IR, UV-Vis and photoluminescence (PL) spectroscopy. The QDs shape was spherical with a particle size between 80-100nm. The synthesis of ZnO/GSH under different experimental conditions and the corresponding coupling with E. Coli species, are presented and discussed.

Keywords

biological synthesis (assembly)nanostructurephotoemission
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1797: Symposium KK – Nanomaterials in Translational Medicine , 2015 , mrss15-2137644
Copyright
Copyright © Materials Research Society 2015 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Tang, et al. , Langmuir, 26, (9), 5271–5275, (2009).CrossRefGoogle Scholar
Gulia, et al. , Adv. Mat. Lett. 4, (12), 876–887, (2013)CrossRefGoogle Scholar
Li, et al. Ind.Eng. Chem. Res., 49, 578–582, (2010).CrossRefGoogle Scholar
Lim, et al. Langmuir, 24, (16), pp. 8857–8863, (2008).CrossRefGoogle Scholar
Gopikrishnan, et al. Nan-Micro Letters, 2, (1), pp. 31–36 (2010).CrossRefGoogle Scholar
Jiang, L.W. et al. , Chem. Phys. Lett. 510, pp. 135–138, (2011).CrossRefGoogle Scholar
Xie, et al. , Journal of Biomedical Science. 19, (14), (2011).Google Scholar
Xiong, et al. , Advanced Materials, 23, (37) 5329–5335, (2013)CrossRefGoogle Scholar
Hessel, C.M., Nano Lett., 11, pp. 947–956, (2011).CrossRefGoogle Scholar
Wang, et al. Analytical Letters, 45, 227–241, (2012).CrossRefGoogle Scholar
Chen, J. et al. , Nano Lett.,7, 5, 1318, (2007).CrossRefGoogle Scholar
Huang, et al. , Nanomater, 10, 1–6, (2010).Google Scholar
Gunalan, et al. Nature Science, 22, (6), 693–700, (2012)Google Scholar
Fujii, et al. Asian J Androl, 5, 231–242, (2003)Google Scholar
Wang, et al. , Journal of biotechnology, 11, (44), 10248–10254, (2012)Google Scholar