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Binding Studies on Resins Imprinted with (S)-naproxen

Published online by Cambridge University Press:  01 February 2011

Yue Hu  and
Robert A. Orwoll
Yue Hu
Affiliation:
Departments of Applied Science and Chemistry College of William and Mary Williamsburg, VA 23187-8795, U.S.A.
Robert A. Orwoll
Affiliation:
Departments of Applied Science and Chemistry College of William and Mary Williamsburg, VA 23187-8795, U.S.A.
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Abstract

Resins were prepared in a free-radical polymerization of 4-vinylpyridine and ethylene glycol dimethacrylate in the presence of (S)-(+)-6-methoxy-α-methyl-2-naphtaleneacetic acid ((S)-naproxen). Initially (S)-naproxen, the imprinted molecule template, was assembled with the monomer 4-vinylpyridine by non-covalent interactions. After the polymerization, stepwise removal of the template left binding sites that retain complementary specificity and affinity. Binding parameters including the maximum number of binding sites and dissociation constant were calculated from the amount of template removed using a two-site Scatchard equation. The results are typical of other systems reported in the literature.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 723: Symposia M/O – Molecularly Imprinted Materials – Chemical and Biological Sensors-Materials and Devices , 2002 , M5.7
Copyright
Copyright © Materials Research Society 2002

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