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Discovery and Development of OMNiMIPs: One MoNomer Molecularly Imprinted Polymers

Published online by Cambridge University Press:  15 March 2011

David A. Spivak ,
Martha Sibrian-Vazquez  and
Stephen Houck
David A. Spivak
Affiliation:
Chemistry, Louisiana State University, 232 Choppin Hall, Baton Rouge, LA, 70803
Martha Sibrian-Vazquez
Affiliation:
Louisiana State University, Baton Rouge, LA, 70803
Stephen Houck
Affiliation:
Louisiana State University, Baton Rouge, LA, 70803
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Abstract

There is enormous potential for the analytical applications of molecularly imprinted polymers (MIPs); for example, the imprinted polymer sites can function as the molecular recognition element of sensors, immunoassays, and separation media. However, difficulties with formulation variables and the need for empirical optimization have inhibited the widespread use of MIPs by the general scientific community. While investigating new crosslinkers for molecular imprinting, we have recently discovered a much simpler approach to MIP formation which utilizes a single crosslinking monomer, NOBE (N, Obismethacryloyl ethanolamine) in addition to template, solvent and initiator (shown in Scheme 1). We have given this molecular imprinting method the acronym “OMNiMIPs” which stands for one monomer molecularly imprinted polymers. This new formulation eliminates variables such as choice of functional monomer (FM) and crosslinker (XL), the ratio of functional monomer to crosslinker (FM/XL), and the ratio of functional monomer to template which normally complicates MIP design. The affects of OMNiMIP performance variables toward molecular recognition indicate significant differences between these new materials and traditional MIPs formulated with ethyleneglycol dimethacrylate (EGDMA) and methacrylic acid (MAA). These differences and the utility of OMNiMIPs will be discussed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1005: Symposium Q – Advances In Photo-Initiated Polymer Processes and Materials , 2007 , 1005-Q05-05
Copyright
Copyright © Materials Research Society 2007

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