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N-isopropylacrylamide-based Copolymers with Time-dependent LCST for a Bioresorbable Carrier

Published online by Cambridge University Press:  01 February 2011

Bae Hoon Lee  and
Brent Vernon
Bae Hoon Lee
Affiliation:
The Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, U.S.A
Brent Vernon
Affiliation:
The Harrington Department of Bioengineering, Arizona State University, Tempe, AZ 85287-9709, U.S.A
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Abstract

To develop a new class of in situ-forming, injectable, and biodegradable polymeric biomaterials based on time-dependent lower critical solution temperature (LCST) properties for localized delivery, copolymers of N-isopropylacrylamide (NIPAAm), 2-hydroxyethyl methacryl lactate (HEMA-lactate) and acrylic acid (AAc) were prepared with varying mole ratios of monomers. The copolymers showed LCST and gelation properties below body temperature in 0.1 N PBS solution of pH 7.4. The LCST and gelation temperature of the copolymers decreased as the HEMA-lactate content of the copolymers was increased. The copolymers also showed time-dependent LCST and gelation properties in 0.1 N PBS solution of pH 7.4 owing to hydrolysis of HEMA-lactate. Hydrolysis of HEMA-lactate caused the polymers to be more hydrophilic, resulting in an increase in LCST and gelation temperature. All the polymers with about 6 mol % AAc exhibited LCST and gelation temperature above body temperature after complete hydrolysis of HEMA-lactate.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA5.6
Copyright
Copyright © Materials Research Society 2005

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References

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