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Advanced Solid State NMR Techniques for the Investigation of the Organic-Mineral Interfaces in Biomaterials

Published online by Cambridge University Press:  31 January 2011

Danielle Laurencin ,
Gilles Guerrero ,
Julien Amalric ,
Christian Bonhomme ,
Christel Gervais ,
Mark E Smith  and
Hubert Mutin
Danielle Laurencin
Affiliation:
danielle.laurencin@univ-montp2.fr, Institut Charles Gerhardt de Montpellier, Montpellier, France
Gilles Guerrero
Affiliation:
guerrero@univ-montp2.fr, Institut Charles Gerhardt de Montpellier, Montpellier, France
Julien Amalric
Affiliation:
julien.amalric@uclouvain.be, Institut Charles Gerhardt de Montpellier, Montpellier, France
Christian Bonhomme
Affiliation:
christian.bonhomme@upmc.fr, Université Pierre et Marie Curie, Paris, France
Christel Gervais
Affiliation:
christel.gervais_stary@upmc.fr, Université Pierre et Marie Curie, Paris, France
Mark E Smith
Affiliation:
M.E.Smith.1@warwick.ac.uk, University of Warwick, Physics, Coventry, United Kingdom
Hubert Mutin
Affiliation:
hubert.mutin@univ-montp2.fr, Institut Charles Gerhardt de Montpellier, Montpellier, France
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Abstract

High resolution solid state NMR experiments were carried out on several compounds, to see how this technique can now be used to investigate in detail the surface structure of different biomaterials. First, because the surface of titanium implants can be functionalized by phosphonic acids, for instance to prevent bacterial adhesion,17O NMR experiments were performed on model TiO2 surfaces functionalized by 17O enriched phosphonic acids, to look at the mode of grafting of these coupling agents. Results bring clear evidence of the formation of Ti-O-P bridges and of the presence of residual P=O and P-OH groups. Second, given that calcium phosphates are widely present in biological hard tissues and synthetic biomaterials, 43Ca correlation experiments were performed on 43Ca enriched materials (hydroxyapatite and calcium benzoate), to see how the proximities between this nucleus and neighbouring atoms can be analyzed. Results show that both Ca…C and Ca…H proximities can be evidenced, and could thus help elucidate interface structures. All in all, these studies should pave the way to future investigations of biomaterials, and in particular of the structure of organic-inorganic interfaces.

Keywords

nuclear magnetic resonance (NMR)biomaterialsurface chemistry
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1236: Symposium SS – Biosurfaces and Biointerfaces , 2009 , 1236-SS08-02
Copyright
Copyright © Materials Research Society 2010

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