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An Investigation of the Release Properties of a Cationic Drug From a Hydrophobic Polyanhydride Matrix as a Function of Dissolution Medium

Published online by Cambridge University Press:  15 February 2011

E. J. Ginsburg ,
T. D. Stultz ,
D. A. Stephens ,
D. Robinson ,
Y. Tian ,
R. M. LIU ,
X. Gao ,
L. C. Li ,
J. E. Quick  and
H.-C. Chang
E. J. Ginsburg
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
T. D. Stultz
Affiliation:
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, IL 60064
D. A. Stephens
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
D. Robinson
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
Y. Tian
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
R. M. LIU
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
X. Gao
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
L. C. Li
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
J. E. Quick
Affiliation:
Current Address: Univ. of Iowa, College of Pharmacy, Div. of Pharmaceutics, Iowa City, IA 52240
H.-C. Chang
Affiliation:
Advanced Drug Delivery, Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064
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Abstract

The dissolution of a drug delivery system consisting of gentamicin sulfate in a hydrophobic polyanhydride matrix has been examined. The in vitro release of gentamicin is a function of the composition of the dissolution medium, with slower release in pH 7.4 buffer than in unbuffered water. This is consistent with an anion exchange taking place under conditions in which carboxylate polymer chain-ends form a poorly soluble salt with gentamicin, and sulfate is released into solution. Results of additional experiments probing this model are digeussed.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 550: Symposium GG/HH/II – Biomedical Materials-Drug Delivery, Implants and Tissue Engr , 1998 , 35
Copyright
Copyright © Materials Research Society 1999

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