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Arborescent Polypeptides for Sustained Drug Delivery

Published online by Cambridge University Press:  05 July 2016

Mosa Alsehli  and
Mario Gauthier
Mosa Alsehli
Affiliation:
Department of Chemistry, Institute for Polymer Research, University of Waterloo, Waterloo, ON N2L 3G1, Canada
Mario Gauthier*
Affiliation:
Department of Chemistry, Institute for Polymer Research, University of Waterloo, Waterloo, ON N2L 3G1, Canada
*
*E-mail: gauthier@uwaterloo.ca
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Abstract

Polypeptides are receiving increasing attention as building blocks to create nanostructures for biomedical applications. The first goal of this investigation was to explore the influence of the reaction conditions in the synthesis of well-defined dendritic graft (arborescent) polypeptides from amine-terminated poly(γ-benzyl L-glutamate) (PBG) chains. The optimization was carried out in terms of the reaction temperature, solvent, reaction time, and mole ratio of reactants and coupling agents. Size exclusion chromatography served to evaluate the grafting reaction in terms of grafting yield (fraction of side chains coupled with the substrate) and coupling efficiency (fraction of coupling sites consumed on the substrate). The maximum grafting yield and coupling efficiency achieved were 67% and 74%, respectively. These arborescent PBG substrates were subsequently grafted with poly(ethylene oxide) segments forming a hydrophilic shell, to obtain water-dispersible unimolecular micelles useful as delivery vehicles for doxorubicin.

Keywords

PolymerizationBiomedicalBiological synthesis (assembly)
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1819: Symposium 4D – New Trends in Polymer Chemistry and Characterization , 2016 , imrc2015s4d-o015
Copyright
Copyright © Materials Research Society 2016 

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References

REFERENCES

Gauthier, M., Möller, M., Macromolecules. 1991, 24, 4548.CrossRefGoogle Scholar
Tomalia, D. A., Hedstrand, D. M., Ferritto, M. S., Macromolecules. 1991, 24, 1435.CrossRefGoogle Scholar
Fréchet, J. M. J., Tomalia, D. A.. Dendrimers and Other Dendritic Polymers; Wiley: West Sussex, UK, 2001.CrossRefGoogle Scholar
Vögtle, F., Richardt, G., Werner, N.. Dendrimer Chemistry: Concepts, Syntheses, Properties, Applications; Wiley-VCH: Weinheim, Germany, 2009.CrossRefGoogle Scholar
Teerstra, S. J., Gauthier, M., Prog. Polym. Sci. 2004, 29, 277.CrossRefGoogle Scholar
Gauthier, M., J. Polym. Sci. A Polym. Chem. 2007, 45, 3803.CrossRefGoogle Scholar
Menjoge, A.R., Kannan, R.M., Tomalia, D.A., Drug Discov. Today. 2010, 15, 171.CrossRefGoogle Scholar
Kannan, R. M., Nance, E., Kannan, S., Tomalia, D.A., J. Int. Med. 2014, 276, 579.CrossRefGoogle Scholar
Kaminskas, L. M., Porter, C. J., Adv. Drug Delivery Rev. 2011, 63, 890.CrossRefGoogle Scholar
Deming, T.J., Prog. Polym. Sci. 2007, 32, 858.CrossRefGoogle Scholar
Valeur, E., Bradley, M., Chem. Soc. Rev. 2009, 38, 606 CrossRefGoogle Scholar
El-Faham, A., Albericio, F., Chem. Rev. 2011, 111, 6557.CrossRefGoogle Scholar
Carpino, L. A., El-Faham, A., Tetrahedron. 1999, 55, 6813.CrossRefGoogle Scholar
Whitton, G., Gauthier, M., J. Polym. Sci., Part A: Polym. Chem. 2013, 51, 5270.CrossRefGoogle Scholar
Poche, D. S., Moore, M. J., Bowles, J. L., Synth. Commun. 1999, 29, 843.CrossRefGoogle Scholar