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Assembly of Gold Nanoparticles on DNA Strands

Published online by Cambridge University Press:  11 February 2011

Michael Noyong ,
Kirsten Gloddek  and
Ulrich Simon
Michael Noyong
Affiliation:
RWTH Aachen, Institute of Inorganic Chemistry, Professor-Pirlet-Str. 1, 52074 Aachen, Germany.
Kirsten Gloddek
Affiliation:
RWTH Aachen, Institute of Inorganic Chemistry, Professor-Pirlet-Str. 1, 52074 Aachen, Germany.
Ulrich Simon
Affiliation:
RWTH Aachen, Institute of Inorganic Chemistry, Professor-Pirlet-Str. 1, 52074 Aachen, Germany.
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Abstract

In this work we report first results on a direct deposition of 2–4nm gold nanoparticles onto DNA strands. In a two step protocol first cis-Pt (cis-diamminedichloroplatinum(II), cis-Pt(NH3)2Cl2) is intercalated into a DNA duplex. In a second step cysteamine stabilized gold nanoparticles are immobilized on DNA due to a ligand exchange (NH3 vs. NH2-R) at the Pt center which was done in solution as well as on surface bound oligonucleotides. The DNA-nanoparticle assemblies are prepared on mica and silicon and are imaged by AFM.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 735: Symposium C – Bioinspired Nanoscale Hybrid Systems , 2002 , C9.4
Copyright
Copyright © Materials Research Society 2003

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References

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