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Biocompatibility of CAD/CAM ORMOCER polymer scaffold structures

Published online by Cambridge University Press:  01 February 2011

A. Doraiswamy ,
T. Patz ,
R. Narayan ,
B. Chichkov ,
A. Ovsianikov ,
R. Houbertz ,
R. Modi ,
R. Auyeung  and
D. B. Chrisey
A. Doraiswamy
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
T. Patz
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
R. Narayan
Affiliation:
Bioengineering Program & School of Material Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA
B. Chichkov
Affiliation:
Laser Zentrum Hannover, Hannover, D-30419, Germany
A. Ovsianikov
Affiliation:
Laser Zentrum Hannover, Hannover, D-30419, Germany
R. Houbertz
Affiliation:
Fraunhofer Institute for Silicate Research, Wurzburg, Germany
R. Modi
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
R. Auyeung
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
D. B. Chrisey
Affiliation:
US Naval Research Laboratory, Washington, DC, USA
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Abstract

A fresh approach with a novel process and a hybrid material is explored for developing designer 3-dimensional functional tissue scaffolds. The process of two photon-induced polymerization generally used for electronic and optical materials is introduced for developing biological scaffolds. Hybrid materials containing organic-inorganic units, ORMOCERs, fabricated with this process are tested for biocompatibility using various cell-types and compared with known standards such as polystyrene and ECM (Extracellular Matrix). Results show good adherence of different cells to these materials, and a growth rate comparable to bioactive materials. Structures with various surface topologies are developed and tested for preferential growth. The study is a first step towards developing bioactive and bioresorbable heterogeneous three-dimensional scaffolds.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 845: Symposium AA – Nanoscale Materials Science in Biology and Medicine , 2004 , AA2.4
Copyright
Copyright © Materials Research Society 2005

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References

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