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Biocompatibility Studies of the Nitinol Thin Films

Published online by Cambridge University Press:  15 February 2011

C.Z. Dinu ,
R. Tanasa ,
V.C. Dinca ,
A. Barbalat ,
C. Grigoriu ,
E.O. Bucur ,
A. Dauscher ,
V. Ferrari DeStefano  and
M. Dinescu
C.Z. Dinu
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, PO Box MG–16, RO 76900, Bucharest, Romania
R. Tanasa
Affiliation:
Pasteur Institute S.A, Calea Giulesti 333, Bucharest, 77 826, Romania
V.C. Dinca
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, PO Box MG–16, RO 76900, Bucharest, Romania
A. Barbalat
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, PO Box MG–16, RO 76900, Bucharest, Romania
C. Grigoriu
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, PO Box MG–16, RO 76900, Bucharest, Romania
E.O. Bucur
Affiliation:
Pasteur Institute S.A, Calea Giulesti 333, Bucharest, 77 826, Romania
A. Dauscher
Affiliation:
Laboratories of Materials Physic (LPM), INPL, Ecole des Mines de Nancy, Parc de Saurupt, F-54042 Nancy, France
V. Ferrari DeStefano
Affiliation:
University of Rome “La Sapienza”, Dept. of Electronics, 00186 Rome, Italy
M. Dinescu
Affiliation:
National Institute for Laser, Plasma and Radiation Physics, PO Box MG–16, RO 76900, Bucharest, Romania
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Abstract

Pulsed Laser Deposition method (PLD) was used to grow nitinol (NiTi) thin films with goal of investigating their biocompatibility. High purity Ni and Ti targets were alternatively ablated in vacuum with a laser beam (λ=355 nm, 10 Hz) and the material was collected on room temperature Ti substrates. X-ray diffraction, scanning electron microscopy, energy dispersive spectroscopy and atomic force microscopy analyses have been performed to investigate the chemical composition, crystalline structure and surface morphology of the NiTi films. The nitinol layers biocompatibility has been tested using as a metric the extent to which the cells adhere during the culture period on the surface of NiTi layers deposited on Ti substrates. Vero and fibroblast cell lines dispersed into MEM (Eagle) solution containing 8% fetal bovine serum, at 37° C, were used for tests. Preliminary studies indicate that the interaction at the interface is specifically controlled by the surface morphology, (especially by surface roughness), and by the chemical state of the surface. Cell behavior after contact with NiTi/Ti structure for different intervals (18, 22 and 25 days for the Vero cells, and after 10 and 25 days for fibroblasts) supports the conclusion that NiTi is a very good candidate as a biocompatible material.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 780: Symposium Y – Advanced Optical Processing of Materials , 2003 , Y4.9
Copyright
Copyright © Materials Research Society 2003

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