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Biomimetic Hemo-compatible Surfaces of Polyurethane by Grafting Copolymer Brushes of Poly(ethylene glycol) and Poly(phosphorylcholine methacrylate)

Published online by Cambridge University Press:  12 April 2012

Dazhi Yang ,
Yakai Feng ,
Marc Behl ,
Andreas Lendlein ,
Haiyang Zhao ,
Musammir Khan  and
Jintang Guo
Dazhi Yang
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin 300072, China.
Yakai Feng
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin 300072, China. Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China, Kantstr. 55, Teltow 14513, Germany
Marc Behl
Affiliation:
Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China, Kantstr. 55, Teltow 14513, Germany Center for Biomaterial Development, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstr. 55, Teltow 14513, Germany.
Andreas Lendlein
Affiliation:
Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China, Kantstr. 55, Teltow 14513, Germany Center for Biomaterial Development, Institute of Polymer Research, Helmholtz-Zentrum Geesthacht, Kantstr. 55, Teltow 14513, Germany.
Haiyang Zhao
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin 300072, China.
Musammir Khan
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin 300072, China.
Jintang Guo
Affiliation:
School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin 300072, China. Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, Tianjin 300072, China, Kantstr. 55, Teltow 14513, Germany
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Abstract

Polyurethanes (PU) have been widely used as biomaterial in recent years, while thrombus may still occur when contacting with blood especially for extended period of time. Poly(ethylene glycol) (PEG) and phosphorylcholine (PC)-based polymers are commonly employed for surface modification to create protein repellent surfaces. PC-based polymers have been investigated as biomimetic materials because PC is the major component in the outer layer of cell membranes. In this study, the biomimetic copolymer brush of PEG-b-poly(2-methacryloyloxyethyl phosphorylcholine) on PU surfaces was synthesized via atom transfer radical polymerization (ATRP) with a surface initiator. The flexible PEG chain was 200 g·mol-1, while the poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) chain length was controlled by the ratio of monomer to sacrificial initiator in solution. The topology of the modified surfaces was characterized by the phase image of atomic force microscopy (AFM) to study the synergy effect between PEG chains and poly(MPC) chains. The unmodified and modified surfaces were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), water contact angle and platelet adhesion. The results demonstrated that efficient grafting of PEG-b-poly(MPC) brushes on the surfaces was achieved. The PU surfaces modified with PEG and phosphorylcholine zwitterionic brushes showed effective resistance to platelet adhesion and high hemocompatibility in vitro. These PEG and PC-grafted PU materials might be potentially applied in blood-contacting materials or devices due to their good mechanical and hemocompatible properties.

Keywords

biomaterialbiomimetic (assembly)adhesion
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1403: Symposium V – Multifunctional Polymer-Based Materials , 2012 , mrsf11-1403-v12-46
Copyright
Copyright © Materials Research Society 2012

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References

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