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Catechol-Bearing Polymeric Nanoparticles for Antioxidant Therapy

Published online by Cambridge University Press:  21 May 2015

Urara Hasegawa ,
Masaki Moriyama ,
Hiroshi Uyama ,
André J. van der Vlies ,
Stéphanie Metzger  and
Martin Ehrbar
Urara Hasegawa
Affiliation:
Frontier Research Base for Young Researchers, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Masaki Moriyama
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Hiroshi Uyama
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
André J. van der Vlies
Affiliation:
Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan. Frontier Research Center, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.
Stéphanie Metzger
Affiliation:
Department of Obstetrics, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
Martin Ehrbar
Affiliation:
Department of Obstetrics, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland.
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Abstract

Polymeric nanoparticles having redox-active catechol moieties, a common structural motif found in naturally-occurring antioxidants, were developed. We synthesized an amphiphilic catechol-bearing polymer that self-assembled to form nanoparticles with a diameter of 126 nm. The nanoparticles showed enhanced ROS-scavenging activity compared to the small catecholic compound dopamine. Furthermore, the nanoparticles inhibited ROS-mediated angiogenesis as shown by the endothelial cell tube formation assay and the chicken chorioallantoic membrane (CAM) assay.

Keywords

polymernanostructurebiomaterial
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1797: Symposium KK – Nanomaterials in Translational Medicine , 2015 , mrss15-2132870
Copyright
Copyright © Materials Research Society 2015 

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References

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