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Comparison of Osteoconduction in Porous Implants of Co-Cr-Mo, Vitreous Carbon, Silicone Rubber and Hydroxyapatite in Rabbit Bone Defects

Published online by Cambridge University Press:  26 February 2011

Edwin C. Shors ,
Gene W. White  and
George Kopchok
Gene W. White
Affiliation:
Interpore International, 18008 Skypark Circle, Irvine, CA 92714;
George Kopchok
Affiliation:
Harbor/UCLA Medical Center, 1000 W. Carson, Torrance, CA 90509
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Abstract

There is a need for new materials which attach to bone. Attachment can occur through bioactive surfaces or porosity. The Replamineform process can be used to produce polymers, metals and ceramics with these properties. In this study, porous implants were manufactured in cobalt-chromemolybdenum (Co-Cr-Mo) vitreous carbon and silicone rubber. The pores were 200 pm in diameter and fully interconnected. The biocompatibility and osteoconduction of these materials was compared to porous hydroxyapatite (Interpore 200 HA). In 10 rabbits, blocks (2mm×3mm×5mm) of each material were implanted subperiosteally onto the femur, or rods (5mm D×10 L) were press-fit into unicortical defects of the proximal tibia. Explants were harvested at 1–6 months, sectioned midsagitally and embedded in plastic for histomorphometry using SEM or bright field microscopy. Bone grew up to and into all implants by two months. However, implants of porous Co-Cr-Mo, vitreous carbon and silicone rubber had less bone than implants of hydroxyapatite. Also, bone formed in direct apposition to hydroxyapatite, but secondly incorporated the other materials. Moreover, implants containing hydroxyapatite in the pores of the Co-Cr-Mo induced more complete and intimate bone ingrowth. This study demonstrates the potential for bone ingrowth and bonding into a range of biocompatible materials with interconnected porosity and the superior osteconduction of porous hydroxyapatite.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 110: Symposium M – Biomedical Materials and Devices , 1987 , 547
Copyright
Copyright © Materials Research Society 1988

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References

1. Ducheyne, P. “Biological Fixation of Implants” in Functional Behavior of Orthopaedic Biomaterials, Hastings, G.W. and Ducheyne, P. (Eds), CRC Press Inc., Boca Raton, FL (1984) p 163.Google Scholar
2. Christel, P., Meunier, A., Leclercq, S., Bouquet, P and Buttazoni, , Development of a carbon-carbon hip prosthesis. J. Biomed. Mat. Res. App. Biomat. 21:181 (1987).Google Scholar
3. VanHoort, R., and Black, M.M. “Silicone Rubber for Medical Applications” in Biocompatibility of Clinical Implant Materials II. William, D.F. (Ed), CRC Press, Inc., Boca Raton, FL (1981), p 79.Google Scholar
4. White, E.W. and Shors, E.C. Biomaterial aspects of Interpore 200 porous hydroxyapatite. Dental clinics of N. Amer. 30, 49 (1986).Google Scholar
5. White, R.A, Weber, J.N. and White, E.W.: Replamineform: A new process for preparing porous ceramic, metal, polymer prosthetic materials. Science 176:922 (1972).CrossRefGoogle ScholarPubMed
6. Dunn, E., Brooks, T., Gordon, B., et al.: Replacement of the canine femoral diaphysis with a porous coated prosthesis. Johns Hopkins Med. J., 145:101 (1979).Google ScholarPubMed
7. White, R.A.: Evaluation of small diameter graft parameters using Replamineform vascular prostheses. In Wright, C.B. (ed): Vascular Grafting. Littleton, Maine, P.S.G. Publishing, Inc. (1983) p 315 Google Scholar
8. Nelson, R.J., White, R.A., Lawrence, R.S., et al.:Development of a microporous tracheal prosthesis. Trans. Am. Soc. Artif. Intern. Organs, 25:8 (1979).CrossRefGoogle ScholarPubMed
9. Roy, D.M., and Linnehan, S.K.: Hydroxyapatite formed from coral skeletal carbonate by hydrothermal exchange. Nature, 247:220 (1974).Google Scholar
10. Albrektsson, T., Branemark, P.I., Hansson, H.A., et al.: Osseointegrated titanium implants. Acta Orthop. Scand., 52:155 (1981).CrossRefGoogle ScholarPubMed
11. Shors, E.C., White, E.W., and Edwards, R.M., “A Method for Quantitative Characterization of Porous Biomaterials Using Automated Image Analysis, in “Quantitative Characterization and Performance of Porous Implants for Hard Tissue Applications. ASTM STP953, Lemons, J.E., Ed., American Society for Testing and Materials, Philadelphia, (1987).Google Scholar