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CPT Encapsulated Silica-titania Hollow Nanoparticle Targeting SK-BR-3 Cells for efficient Anticancer treatment

Published online by Cambridge University Press:  24 February 2015

Yoonsun Jang  and
Jyongsik Jang
Yoonsun Jang*
Affiliation:
Chemical Convergence for Energy & Environment (C2E2,) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea.
Jyongsik Jang*
Affiliation:
Chemical Convergence for Energy & Environment (C2E2,) School of Chemical and Biological Engineering, College of Engineering, Seoul National University (SNU), Seoul, Korea.
*
*Email: ysjang88@snu.ac.kr
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Abstract

HER-conjugated hollow nanoparticles (HER–HNP, ca. 50 nm in diameter) are fabricated using a dissolution and re-deposition method and used to encapsulate camptothecin (CPT). The HER-HNP-CPT is used as an anti-cancer agent for human breast cancer SK-BR-3. It has excellent mono-dispersity and a high loading efficiency for CPT. Two kind of cell lines are used in this study; SK-BR-3 and RAW 264.7. SK-BR-3 and RAW 264.7 are used as targeting and controlling cell line, respectively. When SK-BR-3 cells are treated with HER-HNP-CPT, the viability decreased to 55%, which is ca. 1.5 times higher anti-cancer efficiency in comparison to RAW 264.7. The HER-HNP-CPT system offers a new opportunity to facilitate implementation of a hydrophobic drug for effective anti-cancer treatment of SK-BR-3 cells.

Keywords

biomedicalnanostructurenanoscale
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1725: Symposium I – Emerging 1D and 2D Nanomaterials in Health Care , 2015 , mrsf14-1725-i07-07
Copyright
Copyright © Materials Research Society 2015 

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References

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