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Diffusion of Fibroblast Growth Factor from a Plaster of Paris Carrier

Published online by Cambridge University Press:  15 February 2011

S. Rosenblum ,
S. Frenkel ,
J. Ricci  and
H. Alexander
S. Rosenblum
Affiliation:
Department of Bioengineering Hospital for Joint Diseases, Orthopaedic Institute, 301 East 17th Street, New York, NY 10003
S. Frenkel
Affiliation:
Department of Bioengineering Hospital for Joint Diseases, Orthopaedic Institute, 301 East 17th Street, New York, NY 10003
J. Ricci
Affiliation:
Department of Bioengineering Hospital for Joint Diseases, Orthopaedic Institute, 301 East 17th Street, New York, NY 10003
H. Alexander
Affiliation:
Department of Bioengineering Hospital for Joint Diseases, Orthopaedic Institute, 301 East 17th Street, New York, NY 10003
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Extract

Fibroblast growth factor (FGF) is a polypeptide found in two forms: basic and acidic. The basic form is produced by many more types of cells than the acidic form, although both bind to the same receptor. These proteins act on a variety of mesodermally and ectodermally derived cells, including chondrocytes, glial cells, myoblasts, endothelial cells, cornea and lens epithelia, adrenal cortical cells, ovarian granulosa cells, periosteal fibroblasts, and osteoblasts. Basic FGF was chosen for the present study for a variety of reasons. First, it has significant cross-species homology, with 98.7% correlation between human and both bovine and avian FGF. Less conservation has been observed in the acidic form. In addition, the basic form has been shown to be 30- to 100-fold more potent, depending on the target tissue.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 252: Symposium T – Tissue-Inducing Biomaterials , 1991 , 293
Copyright
Copyright © Materials Research Society 1992

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