Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-14T23:49:40.871Z Has data issue: false hasContentIssue false
  • English
  • Français

Fabrication and antimicrobial effects of silver nanoparticle-poly(N-isopropylacrylamide)-poly(ferrocenylsilane) hydrogel composites

Published online by Cambridge University Press:  13 July 2012

Xiaofeng Sui ,
Xueling Feng ,
Andrea Di Luca ,
Clemens A. van Blitterswijk ,
Lorenzo Moroni ,
Mark A. Hempenius  and
G. Julius Vancso
Xiaofeng Sui
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Xueling Feng
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Andrea Di Luca
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Clemens A. van Blitterswijk
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Lorenzo Moroni
Affiliation:
Department of Tissue Regeneration, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Mark A. Hempenius
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
G. Julius Vancso
Affiliation:
Department of Materials Science and Technology of Polymers, MESA+ Institute for Nanotechnology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands.
Get access

Abstract

Novel hydrogels composed of thermo-responsive poly(N-isopropylacrylamide) (PNIPAM) and redox-responsive poly(ferrocenylsilane) (PFS) macromolecules were formed by photopolymerization. PFS chains bearing acrylate side groups were copolymerized with NIPAM and N,N’-methylenebisacrylamide in tetrahydrofuran in a predetermined ratio under ultraviolet light-emitting diode (UV-LED) irradiation at a wavelength of 365 nm, in the presence of a photoinitiator. Crosslinking occurred smoothly, providing homogeneous hydrogels. The equilibrium swelling ratio, rheology and morphology of these hybrid PNIPAM-PFS-based hydrogels were investigated. In-situ fabrication of silver nanoparticles inside the hydrogel network via reduction of silver nitrate by the PFS chains led to hydrogel composites. These composites showed strong antimicrobial activity while maintaining a high biocompatibility with cells.

Keywords

biomedicalcompositemetal
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1453: Symposium GG/AAA – Functional Hybrid Nanoparticles and Capsules with Engineered Structures and Properties , 2012 , mrss12-1453-gg11-04
Copyright
Copyright © Materials Research Society 2012

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Zhang, H., Han, J. S. and Yang, B., Adv. Funct. Mater. 20, 1533 (2010).Google Scholar
2. Kumar, A., Vemula, P. K., Ajayan, P. M. and John, G., Nat. Mater. 7, 236 (2008).Google Scholar
3. Lv, M., Su, S., He, Y., Huang, Q., Hu, W. B., Li, D., Fan, C. H. and Lee, S. T., Adv. Mater. 22, 5463 (2010).Google Scholar
4. Uygun, M., Kahveci, M. U., Odaci, D., Timur, S. and Yagci, Y., Macromol. Chem. Physic. 210, 1867 (2009).Google Scholar
5. Smidsrød, O. and Guillet, J. E., Macromolecules 2, 272 (1969).Google Scholar
6. Hempenius, M. A., Cirmi, C., Lo Savio, F., Song, J. and Vancso, G. J., Macromol. Rapid Commun. 31, 772 (2010).Google Scholar
7. Sui, X. F., van Ingen, L., Hempenius, M. A. and Vancso, G. J., Macromol. Rapid Commun. 31, 2059 (2010).Google Scholar
8. Whittell, G. R. and Manners, I., Adv. Mater. 19, 3439 (2007).Google Scholar
9. Bellas, V. and Rehahn, M., Angew. Chem. -Int. Edit. 46, 5082 (2007).Google Scholar
10. Rulkens, R., Lough, A. J., Manners, I., Lovelace, S. R., Grant, C. and Geiger, W. E., J. Am. Chem. Soc. 118, 12683 (1996).Google Scholar
11. Wang, H., Wang, X. S., Winnik, M. A. and Manners, I., J. Am. Chem. Soc. 130, 12921 (2008).Google Scholar
12. Porterfield, J. S., Bull. World Health Organ. 22, 373 (1960).Google Scholar
13. Ahmed, S. A., Gogal, R. M. Jr. and Walsh, J. E., J. Immunol. Methods 170, 211 (1994).Google Scholar
14. Potta, T., Chun, C. and Song, S. C., Biomacromolecules 11, 1741 (2010).Google Scholar
15. Heeb, R., Bielecki, R. M., Lee, S. and Spencer, N. D., Macromolecules 42, 9124 (2009).Google Scholar