Hostname: page-component-78c5997874-mlc7c Total loading time: 0 Render date: 2024-11-14T08:08:51.110Z Has data issue: false hasContentIssue false
  • English
  • Français

Fabrication and Applications of Three Dimensional Porous Microwells

Published online by Cambridge University Press:  01 February 2011

Christina L Randall ,
Yevgeniy V Kalinin ,
Anum Azam  and
David Gracias
Christina L Randall
Affiliation:
christina.randall@gmail.com, Johns Hopkins University, Baltimore, Maryland, United States
Yevgeniy V Kalinin
Affiliation:
ykalini1@jhu.edu, Johns Hopkins University, Baltimore, Maryland, United States
Anum Azam
Affiliation:
anumazam@gmail.com, Johns Hopkins University, Baltimore, Maryland, United States
David Gracias
Affiliation:
dgracias@jhu.edu, Johns Hopkins University, Chemical and Biomolecular Engineering, 3400 N Charles Street, 125 Maryland Hall, Baltimore, Maryland, 21218, United States, 410-516-5284, 410-516-5510
Get access

Abstract

In many biological applications, such as cell therapy and drug delivery, there is a need to enhance diffusion by enabling chemical transport in all three dimensions. We highlight this need by comparing diffusion in a conventional two-dimensional (2D) microwell with diffusion in a three-dimensional (3D) cubic microwell using numerical simulations. We also describe the fabrication of hollow polymeric (and biocompatible) cubic microwells and microwell arrays. We emphasize that since the assembly process is compatible with 2D lithographic patterning, porosity can be precisely patterned in all three dimensions. Hence, this platform provides considerable versatility for a variety of applications.

Keywords

microelectro-mechanical (MEMS)biomedicalself-assembly
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1272: Symposia KK/LL/NN/OO/PP – Integrated Miniaturized Materials-From Self-Assembly to Device Integration , 2010 , 1272-KK10-03
Copyright
Copyright © Materials Research Society 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1 Leong, T. G., Randall, C. L., Benson, B. R., Zarafshar, A.M. and Gracias, D. H., Lab Chip 8, 1621 (2008).Google Scholar
2 Gracias, D. H. in Materials and Strategies for Lab-on-a-Chip-Biological Analysis, Cell-Material Interfaces and Fluidic Assembly of Nanostructures, edited by Murthy, S., Khan, S., Ugaz, V. and Zeringue, H.; Materials Research Symposium Proceedings, Volume 1191, San Francisco, CA, (2009)Google Scholar
3 Gimi, B., Leong, T., Gu, Z., Yang, M., Artemov, D., Bhujwalla, Z. M., Gracias, D. H., Biomed. Microdevices 7, 341 (2005)Google Scholar
4 Leong, T., Lester, P., Koh, T., Call, E., Gracias, D. H., Langmuir 23, 8747 (2007)Google Scholar
5 Cho, J. H., Gracias, D. H., Nanoletters 9, 12, 4049 (2009)Google Scholar
6 Leong, T., Zarafshar, A., Gracias, D. H., Small 6, 7, 792 (2010)Google Scholar
7 Cussler, E. L., Diffusion: Mass Transfer in Fluid Systems, Cambridge University Press, (1997)Google Scholar
8 Leong, T. G., Benson, B. R., Call, E. K., Gracias, D. H., Small 4, 1605 (2008)Google Scholar
9 Buchwald, P., Theor. Biol. Med. Model. 6, 13 (2009)Google Scholar