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A Fabrication of a Novel Microfluidic Reactor Microsynthesis of MIP's Particles

Published online by Cambridge University Press:  01 February 2011

Kyung M. Choi ,
John A. Rogers  and
Kenneth J. Shea
Kyung M. Choi
Affiliation:
Department of Chemistry, University of California, Irvine, CA 92697, U.S.A; Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, 07974, U.S.A.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, U.S.A.
John A. Rogers
Affiliation:
Department of Chemistry, University of California, Irvine, CA 92697, U.S.A; Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, 07974, U.S.A.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, U.S.A.
Kenneth J. Shea
Affiliation:
Department of Chemistry, University of California, Irvine, CA 92697, U.S.A; Bell Laboratories, Lucent Technologies, Murray Hill, New Jersey, 07974, U.S.A.; Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, IL 61801, U.S.A.
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Extract

Microfabrication offers us the ability to fabricate numerous active devices at the micro-scale by patterning features on a variety of substrates for developing small devices in nanotechnology. Since materials scientists and chemists have been looking for unconventional approaches in the synthesis of novel materials, we introduce here a novel strategy of fabricating microfluidic reactors. A new microfluidic reactor was designed and fabricated for the microscale synthesis of materials, which has not been possible from conventional bulk syntheses. The microreactor presents a continuous, dynamic droplet generation. Using the microfluidic reactor, we demonstrate here a microfluidic synthesis of molecularly imprinted polymer (MIP), which is useful for bio- or chemical sensor applications due to its specific molecular recognition functions. Since the particle size of MIP's system directly affects their affinity capability in molecular recognitions, uniform MIPs’ particles at the nano- or micro-scale were produced via the microfluidic technique to achieve high sensitivity by developing ‘monoclonal’ MIPs particles, which have only high affinity binding sites.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 872: Symposium J – Micro- and Nanosystems—Materials and Devices , 2005 , J9.4
Copyright
Copyright © Materials Research Society 2005

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References

1(a) Kim, E., Xia, Y. N., and Whitesides, G. M., J. Am. Chem. Soc. 118, 5722 (1996).Google Scholar
(b) Xia, Y. N., Rogers, J. A., Paul, K. E., and Whitesides, G. M., Chem. Rev. 99, 1823 (1999).Google Scholar
2(a) Blanchet, G. and Rogers, J. A., Journal of Imaging Science and Technology 47(4), 296 (2003).Google Scholar
(b) Love, C. J., Anderson, J. R., and Whitesides, G. M., MRS Bulletin 26(7), 523 (2001).Google Scholar
3(a) Choi, K. M. and Rogers, J. A., J. Am. Chem. Soc., 125, 4060 (2003).Google Scholar
(b) Sundar, V., Zaumseil, J., Podzorov, V., Menard, E., Willett, R. L., Someya, T., Gershenson, M. E., Micheal, E., Rogers, J. A., Science 303, 1644 (2004).Google Scholar
4 Conrad, P. G., Nishmura, P. T., Aherne, D., Schwartz, B. J., Wu, D., Fang, N., Zhang, X., Roberts, J., Shea, K. J., Adv. Mater. 11, 5274 (2003).Google Scholar
5 Thorsen, T., Maerkl, S. J. and Quake, S. R., Science, 298, 580 (2002).Google Scholar
6 Duan, X., Niu, C., Sahi, V., Chen, J., Parce, J. W., Empedocles, S., Goldman, J. L., Nature 425, 274 (2003).Google Scholar
7 Wu, T., Mei, Y., Cabral, J., Xu, C., Beers, K. L., J. Am. Chem. Soc. 126, 9880 (2004).Google Scholar
8 Kobayashi, J., Mori, Y., Okamoto, K., Akiyama, R., Ueno, M., Kitamori, T., Kobayashi, S., Science 304, 1305 (2004).Google Scholar
9 Haswell, S. J., Middleton, R. J., O'Sullivan, B., Skelton, V., Watts, P., Styring, P., Chem. Commun. (2001).Google Scholar