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Fast Formation of Biomimetic Ca-P Coatings on Ti6Al4V

Published online by Cambridge University Press:  10 February 2011

F. Barrère ,
P. Layrolle ,
C. A. van Blitterswijk  and
K. de Groot
F. Barrère
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Twente University, The Netherlands
P. Layrolle
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands
C. A. van Blitterswijk
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Twente University, The Netherlands
K. de Groot
Affiliation:
IsoTis BV, Prof. Bronkhostlaan 10, 3723 MB Bilthoven, The Netherlands Leiden University, The Netherlands
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Abstract

The aim of this study was to accelerate the formation of biomimetic Calcium-Phosphate (Ca-P) coatings on Ti6Al4V by using a 5 times more concentrated Simulated Body Fluid (SBFx5) than the regular SBF. The production of SBFx5 was possible by decreasing the pH of the solution to approximately 6 with CO2 gas. The release of this mildly acidic gas allowed the formation of a Ca-P film after 4h of immersion at pH=6.8. The structure of this coating was an amorphous carbonated Ca-P. In addition, our experiments showed that the presence of Mg2+ was absolutely necessary for the Ca-P coating formation on Ti6Al4V substrate. Mg2+ is a crystal growth inhibitor and favored the heterogeneous nucleation. Furthermore, depth profile X-Ray Photoelectron Spectroscopy showed that Ca-P nucleation on the passive Titanium oxide (TiO2) passive layer was initiated by Ca2+ and Mg2+. The attachment of this Ca-P coating resulted probably from chemical bonds such as P-O-Ti and Ca-O-Ti. Ca was more present at the coating/substrate interface than P. Thereby Ca-O-Ti seems to be favored.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 599: Symposium DD – Mineralization in Natural & Synthetic Biomaterials , 1999 , 135
Copyright
Copyright © Materials Research Society 2000

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References

[1] Kokubo, T., Kushitani, H., Sakka, S., Kitsugi, T. and Yamamuro, T., J. Biomed Mater. Res. 24, 1990, pp721–734 Google Scholar
[2] Li, P., Kangasniemi, I., Groot, K. de and Kokubo, T., J. Am. Ceram. Soc. 77, 1994, pp1307–1312 Google Scholar
[3] Peltola, T., Pätsi, M., Rahiala, H., Kangasniemi, I. and Yli-Urpo, A., J. Biomed Mater. Res. 41, 1998, pp504–510 Google Scholar
[4] Kim, H.M., Miyaji, F., Kokubo, T. and Nakamura, T., J Biomed. Mater. Res. 32, 1996, pp409–417 Google Scholar
[5] Wen, H.B., PhD thesis, Leiden Universiteit, 1998 Google Scholar
[6] Combes, C., Rey, C. and Frèche, M., Colloids and surfaces B: Biointerfaces 11, 1998, pp15–27 Google Scholar
[7] Li, P. and Groot, K. de, J Biomed Mater. Res. 27, 1993, pp 129–138 Google Scholar
[8] Healy, K.E. and Ducheyne, P., Biomed, J. Mater. Res. 26, 1992, pp319–338 Google Scholar
[9] Royer, P., PhD thesis, INP Toulouse, 1993, p52 Google Scholar
[10] Lebugle, A., Sallek, B. and Tai, A. Tai, J. Mater. Chem. 9, 1999, pp2511–2515 Google Scholar
[11] Layrolle, P. and Lebugle, A., Chem Mater. 8, 1996, pp 134–144 Google Scholar
[12] Tomazic, B., Tomson, M. and Nancollas, G.H., Archs. Oral Biol. 20, 1975, pp 803–808 Google Scholar
[13] Boskey, A.L. and Posner, A.S., Mat. Res. Bull. 9, 1974, pp907–916 Google Scholar
[14] Thull, R., in Metals as biometarials, edited by Helsen, J.A. and Breme, H.J. (Wiley England 1998), pp 291–315 Google Scholar
[15] Tengvall, P. and Lundstrdm, I., Clin. Mater. 9, 1992, pp115–134 Google Scholar
[16] Bachara, B.N. and Fisher, H.R.A., Calc. Tiss. Res. 3, 1969, pp 348–357 Google Scholar