Hostname: page-component-cd9895bd7-p9bg8 Total loading time: 0 Render date: 2024-12-29T05:46:16.841Z Has data issue: false hasContentIssue false
  • English
  • Français

Hierarchical Self-Assembly of Microgel-Modified Biomaterials Surfaces

Published online by Cambridge University Press:  29 April 2014

Yong Wu ,
Jing Liang ,
Qichen Wang  and
Matthew Libera
Yong Wu
Affiliation:
Department of Chemical Engineering and Materials Science Stevens Institute of Technology, Hoboken, NJ, 07030
Jing Liang
Affiliation:
Department of Chemical Engineering and Materials Science Stevens Institute of Technology, Hoboken, NJ, 07030
Qichen Wang
Affiliation:
Department of Chemical Engineering and Materials Science Stevens Institute of Technology, Hoboken, NJ, 07030
Matthew Libera
Affiliation:
Department of Chemical Engineering and Materials Science Stevens Institute of Technology, Hoboken, NJ, 07030
Get access

Abstract

Microgels are hydrogel particles with micron and sub-micron diameters. They have beendeveloped, studied, and exploited for a broad range of applications because of their uniquecombination of size, soft mechanical properties, and controllable network properties. We havebeen using microgels to modulate the properties of surfaces to differentially control theirinteractions with tissue cells and bacteria. The long-term goal is to create biomaterials thatpromote healing while simultaneously inhibiting infection. Because poly(ethylene glycol) [PEG]is used in a number of FDA-approved products and has well-known antifouling properties, wework primarily with PEG-based microgels. We render these anionic either by copolymerizationwith monomeric acids or by blending with polyacids. Both methods produce pH-dependentnegative charge. Surfaces, both planar 2-D surfaces as well as topographically complex 3-Dsurfaces, can be modified using a hierarchy of non-line-of-sight electrostatic depositionprocesses that create biomaterials surfaces whose cell adhesiveness is modulated by a submonolayerof microgels. Average inter-microgel spacings of 1-2 microns exploit naturaldifferences between staphylococcal bacteria and tissue cells, which open the opportunity todifferentially control surface interactions with them based on length-scale effects. Afterdeposition, the microgels can be loaded with a variety of small-molecule, cationic antimicrobials.The details of loading depend on the relative sizes of the antimicrobials and the microgelnetwork structure as well as on the amount and spatial distribution of electrostatic charge withinboth the microgel and on the antimicrobial. The exposed surface between microgels can befurther modified by the adsorption of adhesion-promoting proteins such as fibronectin viaelectrostatic interaction. This approach combines a rich interplay of microgel structure andchemistry as a key component in a simple and translatable approach to modulate the surfaceproperties of next-generation biomaterials.

Keywords

biomaterialpolymerizationself-assembly
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1622: Symposium E – Fundamentals of Gels and Self-Assembled Polymer Systems , 2014 , pp. 1 - 6
Copyright
Copyright © Materials Research Society 2014 

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

Patel, J.D., et al. ., J Biomed Mater Res A, 80(3): 742–51 (2007).CrossRefGoogle Scholar
Chapman, R.G., et al. ., Langmuir, 17(4): 1225–1233 (2001).CrossRefGoogle Scholar
Desai, N.P., Hossainy, S.F., and Hubbell, J.A., Biomaterials, 13(7): 417–20 (1992).CrossRefGoogle Scholar
Khoo, X., et al. ., J Am Chem Soc, 131(31): 10992–7 (2009).CrossRefGoogle Scholar
Kingshott, P., et al. ., Langmuir, 19(17): 6912–6921 (2003).CrossRefGoogle Scholar
Koh, W.-G., et al. ., Biomedical Microdevices, 5(1): 11–19 (2003).CrossRefGoogle Scholar
Malmsten, M., Emoto, K., and Van Alstine, J.M., Journal of Colloid and Interface Science, 202(2): 507–517 (1998).CrossRefGoogle Scholar
Ostuni, E., et al. ., Langmuir, 17(20): 6336–6343 (2001).CrossRefGoogle Scholar
Roosjen, A., et al. ., J Biomed Mater Res B Appl Biomater, 73(2): 347–54 (2005).CrossRefGoogle Scholar
Wagner, V.E., Koberstein, J.T., and Bryers, J.D., Biomaterials, 25(12): 2247–63 (2004).CrossRefGoogle Scholar
Elbert, D.L. and Hubbell, J.A., Annual Review of Materials Science, 26(1): 365–294 (1996).CrossRefGoogle Scholar
Gombotz, W.R., et al. ., J Biomed Mater Res, 25(12): 1547–62 (1991).CrossRefGoogle Scholar
Gong, X., et al. ., Journal of Polymer Science Part B: Polymer Physics, 38(17): 2323–2332 (2000).3.0.CO;2-6>CrossRefGoogle Scholar
Hucknall, A., Rangarajan, S., and Chilkoti, A., Advanced Materials, 21(23): 2441–2446 (2009).CrossRefGoogle Scholar
Israelachvili, J., Proc Natl Acad Sci U S A, 94(16): 8378–9 (1997).CrossRefGoogle Scholar
Prime, K.L. and Whitesides, G.M., Science, 252(5010): 1164–7 (1991).CrossRefGoogle Scholar
Prime, K.L. and Whitesides, G.M., Journal of the American Chemical Society, 115(23): 10714–10721 (1993).CrossRefGoogle Scholar
Revzin, A., et al. ., Langmuir, 20(8): 2999–3005 (2004).CrossRefGoogle Scholar
Humphries, M., et al. ., FEMS Microbiology Letters, 45(5): 297–304 (1987).CrossRefGoogle Scholar
Krsko, P., Kaplan, J.B., and Libera, M., Acta Biomaterialia, 5(2): 589–596 (2009).CrossRefGoogle Scholar
Roosjen, A., et al. ., Langmuir, 20(25): 10949–55 (2004).CrossRefGoogle Scholar
Wang, Y., et al. ., Advanced Functional Materials, 21(20): 3916–3923 (2011).CrossRefGoogle Scholar
Wang, Y., et al. ., Journal of Polymer Science, Part B: Polymer Physics, 51(21): 1543–1554 (2013).Google Scholar
Wu, Y., Wang, Q., and Libera, M., Macromolecular Symposia, 329(1): 35–40 (2013).CrossRefGoogle Scholar
Wang, Q., Yu, X., and Libera, M., Advanced Healthcare Materials, 2(5): 687–691 (2013).CrossRefGoogle Scholar
Wang, Q., et al. ., Applied Materials and Interfaces., 4(5): 2498–2506 (2012).CrossRefGoogle Scholar
Tu, Z., et al. ., Peptides, 30(8): 1523–8 (2009).CrossRefGoogle ScholarPubMed
Pavlukhina, S., et al. ., Biomacromolecules, 11(12): 3448–3456 (2010).CrossRefGoogle Scholar
Tiller, J.C., et al. ., Proceedings of the National Academy of Sciences, 98(11): 5981–5985 (2001).CrossRefGoogle Scholar