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Lubricin as a Surface Treatment to Reduce Post-operative Biofouling and Infection

Published online by Cambridge University Press:  22 November 2012

George E. Aninwene II ,
Doug Hall ,
Amy Mei ,
Gregory D. Jay  and
Thomas J. Webster
George E. Aninwene II
Affiliation:
School of Engineering, Brown University, Providence, R I 02912 USA
Doug Hall
Affiliation:
School of Engineering, Brown University, Providence, R I 02912 USA
Amy Mei
Affiliation:
School of Engineering, Brown University, Providence, R I 02912 USA
Gregory D. Jay
Affiliation:
Department of Medicine, Section of Emergency Medicine, Brown University, School of Medicine, Providence, R I 02912 USA
Thomas J. Webster
Affiliation:
School of Engineering, Brown University, Providence, R I 02912 USA Department of Orthopaedics, Brown University, Providence, RI 02912 USA
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Abstract

The goal of this research was to investigate the ability of lubricin to prevent bio-fouling of intraocular lenses after surgery, through surface coating trials with lubricin and analogues of the two major sub-units of the lubricin molecule (mucin and vitronectin). Yearly, there are over 6 million surgeries worldwide that involve intraocular lenses (IOLs) 1. However, preventing post-operative biofouling and bacterial infection of these implants remains a challenge 2. Surface modification of IOLs may provide a solution. This study proposes the use of the anti-adhesive protein lubricin (LUB), a glycoprotein found in the synovial fluid, as a means to make polymer surfaces less prone to bacterial adhesion and proliferation; thus, reducing the opportunity for post-operative infection 3. This study used extended bacteria growth trials on tissue cultures polystyrene coated with either lubricin, vitronectin, or mucin to investigate how lubricin and protein sub-regions of lubricin may reduce bacterial adhesion and proliferation.

Keywords

Adhesionbiomedicalcoating
Type
Articles
Information
MRS Online Proceedings Library (OPL) , Volume 1486: Symposium S4A – Nanotechnology-enhanced Biomaterials and Biomedical Devices , 2012 , imrc12-1486-s4a-o002
Copyright
Copyright © Materials Research Society 2012 

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