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New 3D-Biophotopolymers with Selective Surface-cell Interactions for Regenerative Medicine

Published online by Cambridge University Press:  31 January 2011

Christian Heller ,
Martin Schwentenwein ,
Franz Varga ,
Maja Porodec ,
Michaela Schulz-Siegmund ,
Guenter Russmueller ,
Jurgen Stampfl  and
Robert Liska
Christian Heller
Affiliation:
christian.heller@ias.tuwien.ac.at, Vienna University of Technology, Institute of Applied Synthetic Chemistry, Vienna, Austria
Martin Schwentenwein
Affiliation:
martin.schwentenwein@ias.tuwien.ac.at, Vienna University of Technology, Institute of Applied Synthetic Chemistry, Vienna, Austria, Austria
Franz Varga
Affiliation:
franz.varga@osteologie.at, Ludwig Boltzmann Institute of Osteology, Hanusch Hospital Vienna, Vienna, Austria, Austria
Maja Porodec
Affiliation:
porodec@rz.uni-leipzig.de, University of Leipzig, Intitute of Pharmacy, Leipzig, Germany
Michaela Schulz-Siegmund
Affiliation:
schulz@rz.uni-leipzig.de, University of Leipzig, Intitute of Pharmacy, Leipzig, Germany, Germany
Guenter Russmueller
Affiliation:
guenter.russmueller@meduniwien.ac.at, Medical University of Vienna, 5Department of Cranio-, Maxillofacial and Oral Surgery, Vienna, Austria
Jurgen Stampfl
Affiliation:
jstampfl@pop.tuwien.ac.at, TU Wien, Inst. Materials Science and TEchnology, Favoritenstr. 9, Wien, 1040, Austria
Robert Liska
Affiliation:
robert.liska@tuwien.ac.at, TU Vienna, Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163, Vienna, 1060, Austria
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Abstract

Additive Manufacturing Technologies (AMTs) have become an appealing method for the fabrication of 3D cellular scaffolds for tissue engineering and regenerative medicine. To circumvent the use of (meth)acrylate based photopolymers, that suffer from skin irritation and sometimes cytotoxicity, new monomers based on vinyl esters, carbonates and carbamates were prepared. The new materials, giving poly(vinyl alcohol) upon hydrolysis, showed similar results compared to (meth)acrylate references concerning the photoreactivity and mechanical properties, yet being significantly less cytotoxic.

To study the kinetics of hydrolytic degradation, the influence of the different polymerizable groups was investigated by hydrolysis of model compounds under alkaline conditions. We were able to show that the ester moiety of a vinyl ester based polymer could be used to immobilize alkaline phosphatase, therefore they exhibit the ability to immobilize enzymes for selective cell adhesion.

Finally, 3D test structures by AMT techniques could be fabricated and in-vivo testing thereof proofed the biocompatibility of vinyl ester-based scaffolds.

Keywords

photochemicallithography (deposition)biomaterial
Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 1235: Symposium RR – Engineering Biomaterials for Regenerative Medicine , 2009 , 1235-RR04-09
Copyright
Copyright © Materials Research Society 2010

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References

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