Hostname: page-component-6bf8c574d5-956mj Total loading time: 0 Render date: 2025-02-22T23:42:48.142Z Has data issue: false hasContentIssue false
  • English
  • Français

Nonequlibrium Statistical Mechanics of An Ensemble of Vesicles

Published online by Cambridge University Press:  10 February 2011

Leonardo Golubović
Leonardo Golubović*
Affiliation:
Department of Physics, West Virginia University, Morgantown, WV 26506
Get access

Abstract

We investigate far-from-equilibrium dynamics of a polydisperse ensemble of vesicles ( such as liposomes). For that purpose, we construct of a Smoluchowsky-type transport equation incorporating vesicle diffusion and the processes of vesicle fusions and fissions. This approach is used to study the time evolution of an initially monodisperse vesicle ensemble and its important quantities such as the internal aqueous, encapsulated volume. We find three stages of the evolution: (i) an early stage during which EV remains nearly constant, followed by (ii) a stage with a rapid decay of the EV, and, finally (iii) a late stage in which the ensemble approaches the thermodynamic equilibrium. In the far-fromequilibrium stages (i) and (ii), the vesicle ensemble is a “two-fluid” system composed of a polydisperse fluid of small, nearly equilibrated vesicles, coexisting with a fluid of nearly monodisperse vesicles which size evolves due to evaporation-recondensation of the small vesicles. Our picture agrees with experimental data on the EV of lecithin liposomes.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 407: Symposium M – Disordered Materials and Interfaces-Fractals, structure and Dynamics , 1995 , 275
Copyright
Copyright © Materials Research Society 1996

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

REFERENCES

1. Statistical Mechanics of Membranes and Surfaces, edited by Nelson, D. R., Piran, T., and Weinberg, S. (World Scientific, Singapore, 1989).Google Scholar
2. Safran, S. A., Roux, D., Cates, M. E., and Andelman, D., Phys. Rev. Lett. 57, 491 (1986).Google Scholar
3. Golubović, L. and Lubensky, T., Phys. Rev. B 39, 12110 (1989).Google Scholar
4. Golubović, L. and Lubensky, T., Phys. Rev. A 41, 4343 (1990).Google Scholar
5. Huse, D. A. and Leibler, S., J. Phys. (Paris) 49, 605 (1988).Google Scholar
6. Morse, D. and Milner, S., Europhys. Lett 26, 565 (1994), and Phys. Rev. E in press.Google Scholar
7. Golubović, L., Phys. Rev. E50, R2419 (1994).Google Scholar
8. Morse, D., Phys. Rev. E50, R2423 (1994)Google Scholar
9. Liposomes in biological systems, edited by Gregoriades, G. and Allison, A. C. (John Wiley, Chichester, 1980).Google Scholar
10. Liposome: From physical structure to therapeutic applications, edited by Knight, C. K. (Elsevier, Amsterdam, 1991).Google Scholar
11. Liposome technology, edited by Greogoriades, G. (CRC Press, Boca Raton, 1984).Google Scholar
12. Larabee, A. A., Biochemistry 18, 3321 (1989).Google Scholar
13. Hager, A. A. et al., Spectrochem. Acta 49A, 1991 (1993).Google Scholar
14. Mauk, M. et al., Science 207, 309 (1981).Google Scholar
15. Ponpipom, M. M. et. al., J. Med. Chem. 24, 1388 (1981).Google Scholar
16. Wu, P. S., Proc. Natl. Acad. Sci. USA 79, 5490 (1982).Google Scholar